Evidence map›Paper›PMID 34449714›Full record

ArticlePharmacy (Basel, Switzerland)2021

Concomitant Cannabis Misuse and Associations with Depression, Pain and Substance Misuse among Patients Prescribed Opioids.

M Aryana Bryan, Elizabeth Charron, Omolola Adeoye-Olatunde, Jennifer Brown, Udi Ghitza, T John Winhusen, Gerald Cochran

Open access · goldAbstract read
In one paragraph

Article in Pharmacy (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

M Aryana BryanDepartment of Internal Medicine, University of Utah, Salt Lake City, UT 84105, USA.
Elizabeth CharronDepartment of Internal Medicine, University of Utah, Salt Lake City, UT 84105, USA.
Omolola Adeoye-OlatundeCollege of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-2907-3524
Jennifer BrownDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH 45267, USA.
Udi GhitzaCenter for Clinical Trials Network, National Institute on Drug Abuse (NIDA), Bethesda, MD 20892, USA.
T John WinhusenDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH 45267, USA.
Gerald CochranDepartment of Internal Medicine, University of Utah, Salt Lake City, UT 84105, USA.
University of Utah · USUniversity of Cincinnati · USNational Institute on Drug Abuse · USPurdue University West Lafayette · US

Funding

The Ohio Valley Node of the Clinical Trials Network (CTN-0153)UG1DA013732 · NIDA · UNIVERSITY OF CINCINNATI · PI T John WINHUSEN · 2015 to 2026
$42.5M
Greater Intermountain Node (CTN-0151)UG1DA049444 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Gerald T. Cochran, Gerald T. Cochran · 2019 to 2026
$16.8M
NIDA NIH HHS UG1 DA013732NIDA NIH HHS UG1 DA049444NIH HHS UG1DA013732;UG1DA049444
6 · The paper itself

Abstract

backgroundCannabis use is common among individuals with pain who are prescribed opioids, occurring in approximately 10% of this population. This study aims to explore the relationship between non-medical cannabis use and other health risks among individuals filling opioids at community pharmacies.

methodsThis study was an exploratory secondary data analysis of a National Drug Abuse Treatment Clinical Trials Network (CTN)-sponsored study, Validation of a Community Pharmacy-Based Prescription Drug Monitoring Program Risk Screening, examining the relationship between risky cannabis use and depressive symptoms, pain, overdose, and other substance misuse among individuals filling opioid prescriptions in community pharmacies (N = 1440).

resultsParticipants reporting moderate- to high-risk compared to low-risk cannabis use were more likely to report depressive symptoms (adjusted OR = 1.67, 95% CI = 1.11-2.56), history of overdose (adjusted OR = 2.15, 95% CI = 1.34-3.44), and moderate- to high-risk use of alcohol (adjusted OR = 2.10, 95% CI = 1.28-3.45), opioids (adjusted OR = 2.50, 95% CI = 1.67-3.76), sedatives (adjusted OR = 2.58, 95% CI = 1.72-3.86), stimulants (adjusted OR = 4.79, 95% CI = 2.83-8.01), and tobacco (adjusted OR = 3.60, 95% CI = 2.47-5.24).

conclusionsCommunity pharmacies may be valuable sites for identifying, studying, and intervening with substance use problems.

Indexed as

cannabiscommunity pharmacyopioidssubstance use

Identifiers

PMID34449714
PMCPMC8396296
OpenAlexW3192512000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.