ReviewNeurology international2021
A Systematic Review of Severe Neurological Manifestations in Pediatric Patients with Coexisting SARS-CoV-2 Infection.
Review in Neurology international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Multisystem inflammatory syndrome in children: an Umbrella review.Journal of anesthesia · 2024Pooled it
- Multisystem Inflammatory Syndrome Associated With COVID-19 in Children (MIS-C): A Systematic Review of Studies From India.Indian pediatrics · 2022Pooled it
- Outcome of and Risk Factors for Mortality in Pediatric Coronavirus Disease 2019 Encephalitis During the 2022 Omicron Wave in Taiwan: A National Retrospective Study.Open forum infectious diseases · 2026Article
- Acute neurological symptoms in multisystem inflammatory syndrome in children: A case series.Heliyon · 2023Article
- COVID-19 and the Pandemic-Related Aspects in Pediatric Demyelinating Disorders.Seminars in pediatric neurology · 2023Review
- Posterior reversible encephalopathy syndrome and necrotizing enterocolitis in a pediatric patient with medulloblastoma and COVID-19 infection.Pediatric blood & cancer · 2023Article
- Ischemic stroke on SARS-CoV2 vasculitis in a healthy young girl.Health science reports · 2023Article
- The youngest infant with COVID-19-associated necrotizing encephalitis in Asia: A case report.SAGE open medical case reports · 2023Article
- Neuroimaging assessment of pediatric cerebral changes associated with SARS-CoV-2 infection during pregnancy.Frontiers in pediatrics · 2023Article
- Neurological consequences of SARS-CoV-2 infections in the pediatric population.Frontiers in pediatrics · 2023Review
- Causes of Intensive Care Unit Admissions in Children with SARS-CoV-2: A Single-Centre Observational Study.Children (Basel, Switzerland) · 2022Article
- Pediatric SARS-CoV-2-Related Diplopia and Mesencephalic Abnormalities.Neurology. Clinical practice · 2022Article
- Multisystemic Inflammatory Syndrome in Children, A Disease with Too Many Faces: A Single-Center Experience.Journal of clinical medicine · 2022Article
- Neurological effects of COVID-19 in infants and children.Developmental medicine and child neurology · 2022Review
- COVID-19 and neurologic manifestations: a synthesis from the child neurologist's corner.World journal of pediatrics : WJP · 2022Review
- Adverse Events and Safety Profile of the COVID-19 Vaccines in Adolescents: Safety Monitoring for Adverse Events Using Real-World Data.Vaccines · 2022Article
- Neurological complications of COVID-19 in pediatric patients require comprehensive evaluation.Journal of neurovirology · 2022Article
- Acute Neurological Presentation in Children With SARS-CoV-2 Infection.Frontiers in pediatrics · 2022Article
- Neurological Aspects of the Sequelae of COVID-19 in Children.Neuroscience and behavioral physiology · 2022Article
- The Rise of Functional Tic-Like Behaviors: What Do the COVID-19 Pandemic and Social Media Have to Do With It? A Narrative Review.Frontiers in pediatrics · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SARS-CoV-2 infection in children produces mild respiratory symptoms or no symptoms at all in most cases. Some pediatric patients develop a severe complication associated with high mortality, the multisystem inflammatory syndrome in children (MIS-C). In both scenarios, there are reports of neurological manifestations. This article aims to review the cases of pediatric patients with severe neurological issues and a coexisting positive SARS-CoV-2 test. A literature search was performed between March 2020 and May 2021. The results included the data from 41 studies, with 159 children with severe neurological manifestations, within an age range from 24 h to 17 years. The neurological disorders included 38 cases with stroke, 32 with encephalitis, 22 with encephalopathy, and 10 with Guillain-Barre syndrome. Sixty-five out of 159 cases with severe neurological manifestations were diagnosed with MIS-C. Direct neuroinvasion and the exaggerated immune response in some patients seem to be the most critical factors triggering these manifestations. Further research in the ongoing pandemic is needed to elucidate the precise mechanism.
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Registered trials
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