Evidence map›Paper›PMID 34449561›Full record

ArticleCurrent issues in molecular biology2021

A High-Cholesterol Diet Increases Toll-like Receptors and Other Harmful Factors in the Rabbit Myocardium: The Beneficial Effect of Statins.

Alkistis Kapelouzou, Michalis Katsimpoulas, Christos Kontogiannis, Irene Lidoriki, Georgios Georgiopoulos, Christos Kourek, Christos Papageorgiou, Konstantinos S Mylonas, Spyridon Dritsas, Alexandros Charalabopoulos and 1 more

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In one paragraph

Article in Current issues in molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Alkistis KapelouzouClinical, Experimental Surgery & Translational Research, Biomedical Research Foundation Academy of Athens, 11527 Athens, Greece.
Michalis KatsimpoulasClinical, Experimental Surgery & Translational Research, Biomedical Research Foundation Academy of Athens, 11527 Athens, Greece.ORCID 0000-0001-8083-3878
Christos KontogiannisSchool of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Irene LidorikiVascular Unit, First Department of Surgery, Laiko General Hospital, National & Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0003-4608-9621
Georgios GeorgiopoulosSchool of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Christos KourekSchool of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0003-4348-2153
Christos PapageorgiouSchool of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Konstantinos S MylonasVascular Unit, First Department of Surgery, Laiko General Hospital, National & Kapodistrian University of Athens, 11527 Athens, Greece.
Spyridon DritsasSecond Department of Surgery, Aretaieio Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0002-0435-5306
Alexandros CharalabopoulosVascular Unit, First Department of Surgery, Laiko General Hospital, National & Kapodistrian University of Athens, 11527 Athens, Greece.
Dennis V CokkinosClinical, Experimental Surgery & Translational Research, Biomedical Research Foundation Academy of Athens, 11527 Athens, Greece.
National and Kapodistrian University of Athens · GRAcademy of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA high-cholesterol diet (HCD) induces vascular atherosclerosis through vascular inflammatory and immunological processes via TLRs. The aim of this study is to investigate the mRNA expression of TLRs and other noxious biomarkers expressing inflammation, fibrosis, apoptosis, and cardiac dysfunction in the rabbit myocardium during (a) high-cholesterol diet (HCD), (b) normal diet resumption and (c) fluvastatin or rosuvastatin treatment.

methodsForty-eight male rabbits were randomly divided into eight groups (

resultsmRNA of TLRs 2, 3, 4 and 8; interleukin-6; TNF-a; metalloproteinase-2; tissue inhibitor of metalloproteinase-1; tumor protein 53; cysteinyl aspartate specific proteinase-3; and brain natriuretic peptide (BNP) increased in HCD. Statins but not resumption of a normal diet decreased levels of these biomarkers and increased levels of antifibrotic factors.

conclusionsHCD increases the levels of TLRs; inflammatory, fibrotic and apoptotic factors; and BNP in the rabbit myocardium. Atherogenic diets adversely affect the myocardium at a molecular level and are reversed by statins.

Indexed as

AnimalsCholesterol, DietaryDisease Models, AnimalFluvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsHypercholesterolemiaInflammationInterleukin-6MaleMyocardiumRabbitsRosuvastatin CalciumToll-Like ReceptorsTumor Necrosis Factor-alphaCholesterol, DietaryFluvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsInterleukin-6Rosuvastatin CalciumToll-Like ReceptorsTumor Necrosis Factor-alphabiomarkershigh-cholesterol dietinflammationmyocardiumstatinstoll-like receptors

Identifiers

PMID34449561
PMCPMC8928938
OpenAlexW3186945447

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.