ArticleMedicine2021
Polypharmacy is associated with malnutrition and activities of daily living disability among daycare facility users: A cross-sectional study.
Article in Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- A Critical View over the Newest Antidiabetic Molecules in Light of Efficacy-A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- Association of anorexia/appetite loss with malnutrition and mortality in older populations: A systematic literature review.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Association Between Polypharmacy and Physical Function in Middle-aged Adults: Findings from the CARDIA Function Study.Journal of general internal medicine · 2026Article
- Artificial Intelligence-Based Hospital Malnutrition Screening: Validation of a Novel Machine Learning Model.Applied clinical informatics · 2025Article
- Effect of Instant Messaging-Based Integrated Healthcare on Medical Service Use and Care Outcomes in Patients with Disabilities.Healthcare (Basel, Switzerland) · 2025Article
- The impact of polypharmacy and oral nutritional supplementation on nutritional status in patients residing in a long-term care facility.Frontiers in nutrition · 2025Article
- Identifying Malnutrition Risk in the Elderly: A Single- and Multi-Parameter Approach.Nutrients · 2024Article
- Advancing the Understanding of Malnutrition in the Elderly Population: Current Insights and Future Directions.Nutrients · 2024Review
- The Link between Inflammation, Lipid Derivatives, and Microbiota Metabolites in COVID-19 Patients: Implications on Eating Behaviors and Nutritional Status.International journal of molecular sciences · 2024Review
- Association between polypharmacy and chronic kidney disease among community-dwelling older people: a longitudinal study in southern China.BMC nephrology · 2024Article
- The impact of falls on activities of daily living in older adults: A retrospective cohort analysis.PloS one · 2024Article
- Malnutrition in Hospitalized Old Patients: Screening and Diagnosis, Clinical Outcomes, and Management.Nutrients · 2022Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
abstractPolypharmacy influences malnutrition and activities of daily living (ADL) in older individuals owing to side effects such as anorexia. This study aimed to examine whether polypharmacy (5 or more drugs) is associated with malnutrition and ADL disability among daycare facility users.This cross-sectional study was performed in a daycare facility specializing in rehabilitation. Malnutrition was defined according to the Global Leadership Initiative on Malnutrition criteria and ADL disability according to the "criteria for determination of the daily life independence level (bedridden level) of elderly with disabilities."In total, 103 of the 134 included individuals were analyzed. Thirty-three (32.0%) participants were malnourished, 46 (44.7%) had ADL disability, 58 (56.3%) qualified as cases of polypharmacy, and 9 (8.7%) experienced loss of appetite. Multivariable logistic regression analysis showed that polypharmacy was independently associated with malnutrition and ADL disability. Separate analyses of each type of drug revealed that proton pump inhibitors (that impair protein absorption and assimilation), anticonstipation drugs, and antihypertensive drugs were associated with malnutrition, whereas proton pump inhibitors, anticonstipation drugs, antidyslipidemia drugs, and antidiabetic drugs were associated with ADL disability. The only factor related to anorexia was the loss of pleasure of eating, which in turn was related to psychological stress.The side effects of polypharmacy among individuals with malnutrition and ADL disability may include impaired protein absorption and assimilation caused by proton pump inhibitors, but not anorexia. Further multicenter prospective studies are required to confirm these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.