Evidence map›Paper›PMID 34449303›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

Endotyping Sleep Apnea One Breath at a Time: An Automated Approach for Separating Obstructive from Central Sleep-disordered Breathing.

Ankit Parekh, Thomas M Tolbert, Anne M Mooney, Jaime Ramos-Cejudo, Ricardo S Osorio, Marcel Treml, Simon-Dominik Herkenrath, Winfried J Randerath, Indu Ayappa, David M Rapoport

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. The importance of classifying central hypopneas: a call to action.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Review
  3. Review
  4. Inspiratory positive pressure modulation to minimize respiratory control instability.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  5. Insights, recommendations, and research priorities for central sleep apnea: report from an expert panel.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  6. Central sleep apnea: realignment required.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  7. Review
  8. Review
  9. Review
  10. Central sleep apnoea: not just one phenotype.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  11. Long-term health outcomes for patients with obstructive sleep apnea: placing the Agency for Healthcare Research and Quality report in context-a multisociety commentary.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Distinguishing central from obstructive hypopneas on a clinical polysomnogram.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ankit ParekhDivision of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Thomas M TolbertDivision of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Anne M MooneyDivision of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Jaime Ramos-CejudoCenter for Sleep and Brain Health, Department of Psychiatry, New York University Grossman School of Medicine, New York, New York; and.
Ricardo S OsorioCenter for Sleep and Brain Health, Department of Psychiatry, New York University Grossman School of Medicine, New York, New York; and.
Marcel TremlInstitute of Pneumology at the University of Cologne, Department of Pneumology and Allergology, Center of Sleep Medicine and Respiratory Care, Bethanien Hospital, Solingen, Germany.
Simon-Dominik HerkenrathInstitute of Pneumology at the University of Cologne, Department of Pneumology and Allergology, Center of Sleep Medicine and Respiratory Care, Bethanien Hospital, Solingen, Germany.
Winfried J RanderathInstitute of Pneumology at the University of Cologne, Department of Pneumology and Allergology, Center of Sleep Medicine and Respiratory Care, Bethanien Hospital, Solingen, Germany.
Indu AyappaDivision of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
David M RapoportDivision of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Icahn School of Medicine at Mount Sinai · USUniversity of Cologne · DENew York University · US

Funding

Research Education ComponentP30AG066512 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Mary Sherman Mittelman · 2020 to 2026
$28.4M
Slow wave sleep (SWS) and the effect of African ancestry on amyloid burden, a longitudinal studyR01AG056531 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JEAN-LOUIS, GIRARDIN, OSORIO, RICARDO S · 2018 to 2022
$6.7M
Sleep Aging and Risk for Alzheimer's disease-Resubmission-1R01AG056031 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI OSORIO, RICARDO S · 2018 to 2022
$4.4M
Mentoring Research in the Physiology of Sleep Disordered BreathingK24HL109156 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI AYAPPA, INDU A · 2013 to 2023
$1.0M
Sustained Attention Neuroimaging in Sleep ApneaK25HL151912 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PAREKH, ANKIT ASHOK · 2021 to 2025
$775k
Brain Sleep Clearance of Amyloid-Beta Peptides Study (Brain SCRAPS)R21AG049348 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI OSORIO, RICARDO S · 2015 to 2016
$454k
NHLBI NIH HHS K24 HL109156NHLBI NIH HHS K25 HL151912NIA NIH HHS P30 AG066512NIA NIH HHS R01 AG056031NIA NIH HHS R01 AG056531NIA NIH HHS R21 AG049348
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Clinical Decision RulesPolysomnographyAdultAgedAirway ResistanceDiagnosis, DifferentialFemaleHumansLogistic ModelsMaleMiddle AgedReproducibility of ResultsROC CurveSleep Apnea, CentralSleep Apnea, Obstructiveairflow limitationesophageal pressure swingsmachine learningsleep apneaupper airway resistance

Identifiers

PMID34449303
PMCPMC8865720
OpenAlexW3193383706

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.