Evidence map›Paper›PMID 34449302›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

Increased Angiotensin-Converting Enzyme 2 and Loss of Alveolar Type II Cells in COVID-19-related Acute Respiratory Distress Syndrome.

Ludovic Gerard, Marylene Lecocq, Caroline Bouzin, Delphine Hoton, Gregory Schmit, Joao Pinto Pereira, Virginie Montiel, Thomas Plante-Bordeneuve, Pierre-François Laterre, Charles Pilette

Open access · hybridAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Use of remdesivir in patients with COVID-19: a systematic review and meta-analysis.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Equip your vehicle for the right terrain: Using features of local pathology to guide engineering of targeted drug delivery systems.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Review
  7. Proteomic Analysis of COVID-19 Infection.Advances in experimental medicine and biology · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Interactions of SARS-CoV-2 with Human Target Cells-A Metabolic View.International journal of molecular sciences · 2024
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Ludovic GerardService de Soins Intensifs.ORCID 0000-0002-8842-6270
Marylene LecocqPôle de pneumologie, Institut de Recherche Expérimentale et Clinique.
Caroline BouzinPlateforme d'imagerie (2IP), Institut de Recherche Expérimentale et Clinique.
Delphine HotonService d'Anatomopathologie, and.
Gregory SchmitService d'Anatomopathologie, and.
Joao Pinto PereiraService de Soins Intensifs.
Virginie MontielService de Soins Intensifs.
Thomas Plante-BordeneuvePôle de pneumologie, Institut de Recherche Expérimentale et Clinique.
Pierre-François LaterreService de Soins Intensifs.
Charles PilettePôle de pneumologie, Institut de Recherche Expérimentale et Clinique.
European Society of Intensive Care Medicine · BEInstitut Universitaire de Recherche Clinique · FRService de la Santé Publique · CHCliniques Universitaires Saint-Luc · BEInstitut d'Imagerie Biomédicale · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedAlveolar Epithelial CellsAngiotensin-Converting Enzyme 2BiomarkersCase-Control StudiesCOVID-19FemaleHumansImmunohistochemistryLogistic ModelsMaleMiddle AgedPeptidyl-Dipeptidase AProportional Hazards ModelsRespiratory Distress SyndromeACE2 protein, humanACE protein, humanAngiotensin-Converting Enzyme 2BiomarkersPeptidyl-Dipeptidase Aangiotensin-converting enzymeangiotensin-converting enzyme 2ARDSCOVID-19type 2 alveolar epithelial cells

Identifiers

PMID34449302
PMCPMC8663012
OpenAlexW3193433106

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.