SynthesisAging clinical and experimental research2022
Meta-analysis of clinical trials focusing on hypertonic dextrose prolotherapy (HDP) for knee osteoarthritis.
Synthesis in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Non-Biologic Injections in Sports Medicine.Current reviews in musculoskeletal medicine · 2026Review
- Recent Advances in Ultrasound-Guided Hydrodissection and Dextrose Prolotherapy for Musculoskeletal Pain: A Target-Based State-of-the-Art Narrative Review.Life (Basel, Switzerland) · 2026Review
- The evolving landscape of minimally invasive procedures in musculoskeletal diseases-Part II.Frontiers in medicine · 2026Review
- Rapid Decrease in Dextrose Concentration After Intra-Articular Knee Injection: Implications for Mechanism of Action of Dextrose Prolotherapy.Biomedicines · 2025Article
- Advanced Non-Operative Interventions for Anterior Knee Pain.Current reviews in musculoskeletal medicine · 2024Review
- Is there a genetic relationship between blood glucose and osteoarthritis? A mendelian randomization study.Diabetology & metabolic syndrome · 2024Article
- Review
- A Review of Current Approaches to Pain Management in Knee Osteoarthritis with a Focus on Italian Clinical Landscape.Journal of clinical medicine · 2024Review
- Interventional Techniques for the Management of Knee Osteoarthritis: A Literature Review.Cureus · 2023Review
- A novel infrapatellar approach of ultrasound-guided intra-articular injection of the knee from both lateral and medial side: a case series.Therapeutic advances in musculoskeletal disease · 2023Article
- Current and Novel Therapeutics for Articular Cartilage Repair and Regeneration.Therapeutics and clinical risk management · 2023Review
- A comparison between hypertonic dextrose prolotherapy and conventional physiotherapy in patients with knee osteoarthritis.Medicine internationalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Hypertonic dextrose prolotherapy (HDP) is an injection of a concentrated dextrose solution for the purpose of local treatment of musculoskeletal pain and possible enhancement of repair mechanisms. This systematic review and meta-analysis examines the clinical utility of HDP injection for treatment of knee osteoarthritis (OA). Randomized controlled trials (RCTs) utilizing HDP to treat knee OA were retrieved from MEDLINE, EMBASE, and Cochrane Library (CENTRAL). Identification and inclusion of RCTs utilizing intra-articular and extra-articular administration of HDP vs administration of other injectate or physical therapy as control for knee OA were included. Primary clinical outcomes were changes in knee WOMAC, pain and function score. Secondary outcomes were adverse events related to HDP. For continuous outcomes with same or different measurements, we calculated, respectively the weighted mean difference (WMD) or the standardized mean difference (SMD), respectively. Results were pooled using DerSimonian and Laird random effect models across the included studies and heterogeneity between studies was estimated using the I
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.