Evidence map›Paper›PMID 34449060›Full record

ArticleJournal of physiology and biochemistry2021

Short-term exercise affects cardiac function ex vivo partially via changes in calcium channel levels, without influencing hypoxia sensitivity.

Tytti-Maria Uurasmaa, Tomi Streng, Milla Alkio, Ilkka Heinonen, Katja Anttila

Open access · hybridAbstract read
In one paragraph

Article in Journal of physiology and biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Tytti-Maria UurasmaaDepartment of Biology, University of Turku, 20014, Turku, Finland. tmeuur@utu.fi.ORCID http://orcid.org/0000-0002-4424-554X
Tomi StrengDepartment of Biology, University of Turku, 20014, Turku, Finland.ORCID https://orcid.org/0000-0002-8785-1216
Milla AlkioDepartment of Biology, University of Turku, 20014, Turku, Finland.
Ilkka HeinonenTurku PET Centre, University of Turku, and Turku University Hospital, 20014, Turku, Finland.ORCID https://orcid.org/0000-0001-8608-4839
Katja AnttilaDepartment of Biology, University of Turku, 20014, Turku, Finland.ORCID https://orcid.org/0000-0002-0128-0943
University of Turku · FIPoznan University of Medical Sciences · PL

Funding

Academy of Finland 324243
6 · The paper itself

Abstract

Exercise is known to improve cardiac recovery following coronary occlusion. However, whether short-term exercise can improve cardiac function and hypoxia tolerance ex vivo independent of reperfusion injury and the possible role of calcium channels in improved hypoxia tolerance remains unknown. Therefore, in the current study, heart function was measured ex vivo using the Langendorff method at different oxygen levels after a 4-week voluntary wheel-running regimen in trained and untrained male mice (C57Bl/6NCrl). The levels of cardiac Ca

Indexed as

CalciumMyocardiumAnimalsHypoxiaMaleMiceMyocytes, CardiacRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumSarcoplasmic Reticulum Calcium-Transporting ATPasesSodium-Calcium ExchangerCalciumRyanodine Receptor Calcium Release ChannelSarcoplasmic Reticulum Calcium-Transporting ATPasesSodium-Calcium ExchangerCACNAEx vivoHeart functionLangendorffNCXPressure generationRyRSERCATraining

Identifiers

PMID34449060
PMCPMC8605979
OpenAlexW3195112570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.