Evidence map›Paper›PMID 34448981›Full record

SynthesisDigestive diseases and sciences2022

Celiac Disease Is Associated with Microscopic Colitis in Refractory Cases in Adults: A Systematic Review and Meta-Analysis of Observational Studies.

Muhammad Aziz, Hossein Haghbin, Raja Samir Khan, Zubair Khan, Simcha Weissman, Faisal Kamal, Wade Lee-Smith, Saurabh Chandan, Joseph D Feuerstein, Douglas G Adler

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Update on the Epidemiology and Management of Microscopic Colitis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Muhammad Aziz *Division of Gastroenterology and Hepatology, University of Toledo, Toledo, OH, USA.
Hossein Haghbin *Department of Internal Medicine, University of Toledo, Toledo, OH, USA.
Raja Samir KhanDepartment of Internal Medicine, West Virginia University, Morgantown, WV, USA.
Zubair KhanDivision of Gastroenterology and Hepatology, University of Texas at Houston, Houston, TX, USA.
Simcha WeissmanDepartment of Medicine, Hackensack University - Palisades Medical Center, North Bergen, NJ, USA.
Faisal KamalDivision of Gastroenterology, University of California, San Francisco, CA, USA.
Wade Lee-SmithUniversity of Toledo Libraries, University of Toledo, Toledo, OH, USA.
Saurabh ChandanGastroenterology Unit, CHI Health Creighton University Medical Center, Omaha, NE, USA.
Joseph D FeuersteinDivision of Gastroenterology, Hepatology, and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Douglas G AdlerDepartment of Gastroenterology, Centura Health, Center for Advanced Therapeutic Endoscopy, Denver, CO, USA. dougraham2001@gmail.com.ORCID 0000-0003-3214-6285
University of Toledo · USBeth Israel Deaconess Medical Center · USCHI Health Creighton University Medical Center - Bergan Mercy · USDenver Health Medical Center · USHackensack University Medical Center · USThe University of Texas Health Science Center at Houston · USUniversity of California, San Francisco · USWest Virginia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMicroscopic colitis and Celiac disease have been shown to occur concomitantly, but their relationship has yet to be systematically evaluated. Some patients with refractory microscopic colitis may have simultaneous celiac disease, and the converse is also true.

aimsWe performed a systematic review and meta-analysis of observational studies to assess the prevalence and possible association between these two conditions.

methodsPubMed, Embase, Cochrane, Web of Science, SciELO, and CINAHL Plus were systematically searched through January 26, 2021, to include relevant observational studies assessing the prevalence of microscopic colitis in celiac disease population or vice versa. DerSimonian-Laird approach using random effects was used to pool data and compare outcomes. Pooled prevalence, 95% confidence interval (CI), and p values (where applicable) were calculated.

resultsFive studies (with 2589 patients, age range 39.5-52 years and females 66.6%) and 21 studies (with 7186 patients, age range 46.4-65.8 years and females 76.3%) were included assessing the prevalence of microscopic colitis in refractory celiac disease and celiac disease in refractory microscopic colitis cohort. The overall prevalence was 4.5% (2.6-6.3%) and 6.7% (5.2-8.1%), respectively. Five studies showed higher odds of celiac disease diagnosis in the refractory microscopic colitis population compared to the control group (OR 8.12, CI 4.92-13.41, p < 0.001).

conclusionCeliac disease and microscopic colitis are concomitantly prevalent in a subset of population with either refractory diagnosis. Clinicians should explore alternate diagnosis when one condition has been appropriately treated and patients continue to have refractory symptoms.

Indexed as

Celiac DiseaseColitis, MicroscopicAdultCohort StudiesFemaleHumansMiddle AgedPrevalenceAdultsCeliac diseaseCollagenous colitisDiarrheaLymphocytic colitisMicroscopic colitisPrevalence

Identifiers

PMID34448981
OpenAlexW3193744497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.