ArticleDigestive diseases and sciences2022
Symptom Frequency and Distress Underestimated in Decompensated Cirrhosis.
Article in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Evaluation of the impact of an interdisciplinary team scheduling model on psychological outcomes in patients with decompensated cirrhosis.World journal of hepatology · 2026Trial
- Comparison Between Helpful and Missing Resources Identified by Patients with End-Stage Liver Disease and Their Caregivers: A Content Analysis.Nursing reports (Pavia, Italy) · 2026Article
- Distinct Patterns of Dyadic Mental Health in Patients with End-Stage Liver Disease and Their Care Partners.Healthcare (Basel, Switzerland) · 2026Article
- Trajectories of symptom burden and associated factors in patients with liver cirrhosis: a prospective study.Frontiers in medicine · 2026Article
- Longitudinal changes in physical and psychological outcomes in spousal vs. non-spousal caregivers for patients with end-stage liver disease.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Increasing Healthcare System Empathy for Patients with Advanced Liver Disease: My Top 10 Lessons in Palliative Hepatology.Digestive diseases and sciences · 2024Article
- The Edmonton Symptom Assessment System is a valid, reliable, and responsive tool to assess symptom burden in decompensated cirrhosis.Hepatology communications · 2024Article
- Analysis of hope level and its influencing factors in patients with decompensated cirrhosis.Nursing open · 2023Observational
- Symptom Classes in Decompensated Liver Disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022Article
- Review article: current and emerging therapies for the management of cirrhosis and its complications.Alimentary pharmacology & therapeutics · 2022Review
- The Impact of Social Workers in Cirrhosis Care: a Systematic Review.Current treatment options in gastroenterology · 2022Review
- Muscle cramps in cirrhosis.Clinical liver diseaseArticle
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundStudies assessing multiple symptoms and the distress of these symptoms in decompensated cirrhosis are lacking.
aimsThe aims of this study were to assess symptom prevalence and distress among patients with decompensated cirrhosis and to describe medical management of the most prevalent symptoms.
methodsPatients were recruited from hepatology clinics within two health-care systems. Eligibility criteria included a model for end-stage liver disease (MELD-Na) score ≥15. Patients completed the Condensed Memorial Symptom Assessment Scale and Patient Health Questionnaire. Comparative statistics were used to analyze the cross-sectional survey data.
resultsOf the sample (n = 146), most patients were Child-Turcotte-Pugh (CTP) class B (49.7%) and C (46.2%). Mean age was 56.5 years, 65.1% were male, and 88.4% were white. Average MELD-Na score was 19.1 ± 4.5. The most prevalent symptoms were lack of energy and feeling drowsy while the most distressing were lack of energy and difficulty sleeping. Only 24 patients (16.4%) were treated for their difficulty sleeping with sleep medication. Importantly, those prescribed sleep medications had similar distress (3.9 ± 1.2 vs. 3.5 ± 1.2, p = 0.229) compared with patients not prescribed sleep medications. Opioids were prescribed to 57 (39.0%) patients; antidepressants to 34 (23.3%). Forty patients (27.4%) who reported moderate or greater depression were not prescribed an antidepressant.
conclusionsThe study highlights the multiple symptoms and distress experienced by patients with decompensated cirrhosis, and the need for improved medical management by health-care providers through enhanced awareness and attention to these complex symptoms. Future research should focus on improvements in symptom management.
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