ArticleEuropean journal of clinical pharmacology2022
Improving medication adherence and effective prescribing through a patient-centered prescription model in patients with multimorbidity.
Article in European journal of clinical pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06897410 (Reforça't), which is not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reforça't: A Randomized Community Clinical Trial With a Social and Healthcare Approach to Improve Functional Outcomes in Patients With Chronic Cardiac, Respiratory, or Mixed Conditions After Hospital Discharge
Who cites it
25 citing papers in PubMed, 31 citations in OpenAlex.
- Patient and general practitioner experiences of implementing a medication review intervention in older people with multimorbidity: Process evaluation of the SPPiRE trial.Health expectations : an international journal of public participation in health care and health policy · 2022Trial
- Application of a person-centered prescription model improves pharmacotherapeutic indicators and reduces costs associated with pharmacological treatment in hospitalized older patients at the end of life.Frontiers in public health · 2022Trial
- The impact of stigma on medication adherence among patients with multimorbidity: mediation analysis of medication literacy.Frontiers in public health · 2026Article
- Rheumatoid Arthritis Exploratory Survey: Voices of Three Key Stakeholders (Patients, Caregivers, and Health Care Professionals).Clinical medicine insights. Arthritis and musculoskeletal disorders · 2026Article
- Applying a multidisciplinary intervention for drug adequacy in an intermediate care hospital (AMIDA-ICH): study protocol of a complex intervention trial.Frontiers in medicine · 2026Article
- Patterns and determinants of medication adherence among older adult patients with diabetes in Korea: insights from a nationwide survey.BMC geriatrics · 2025Article
- Frailty, comorbidity, and multimorbidity and their relation with medications adherence in primary care older adults.European geriatric medicine · 2025Article
- Multicomponent intervention to tailor prescriptions to patients with dementia in an intermediate care hospital: pre-post quasi experimental study.BMC geriatrics · 2025Article
- Factors Affecting Medication Adherence in Middle-Aged and Elderly Patients in China: A Cross-Sectional Study.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Pharmacist-Led Interventions to Improve Medication Adherence Among Patients with Multimorbidity: A Scoping Review.Patient preference and adherence · 2025Review
- Association of medication regimen complexity index with ADRs in HIV/AIDS patients: a retrospective cohort study.Frontiers in pharmacology · 2025Article
- Treatment Nonadherence among Multimorbid Chronic Disease Patients: Evidence from 3515 Subjects in Indonesia.Medicina (Kaunas, Lithuania) · 2024Article
- Compliance status and influencing factors of anticoagulation therapy in outpatient undergoing major orthopedic surgery.Archives of orthopaedic and trauma surgery · 2024Article
- Drug-Related Problems in Elderly Patients Attended to by Emergency Services.Journal of clinical medicine · 2023Review
- Intersection and Considerations for Patient-Centered Care, Patient Experience, and Medication Experience in Pharmacogenomics.Pharmacy (Basel, Switzerland) · 2023Review
- What Do Students' Questionnaire Responses Tell Us about Their Language around Person-Centred Care? An Exploratory Sentiment Analysis.Healthcare (Basel, Switzerland) · 2023Article
- Design a Clinical Research Protocol: Influence of Real-World Setting.Healthcare (Basel, Switzerland) · 2023Review
- An Ontology-Based Approach to Improving Medication Appropriateness in Older Patients: Algorithm Development and Validation Study.JMIR medical informatics · 2023Article
- Association between medication literacy and medication adherence and the mediating effect of self-efficacy in older people with multimorbidity.BMC geriatrics · 2023Article
- Use of Motivational Interviewing in Older Patients with Multiple Chronic Conditions and Their Informal Caregivers: A Scoping Review.Healthcare (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeThis study aimed to assess the impact of the patient-centered prescription (PCP) model in medication adherence and effective prescribing in patients with multimorbidity.
methodsUncontrolled before-after study in an intermediate care facility in a mixed urban-rural district. Inpatients aged ≥ 65 years with multimorbidity exposed to polypharmacy before hospital admission were consecutively enrolled. Every patient's treatment plan was analyzed through the PCP model, which includes interventions aimed at improving medication adherence. The primary endpoint was the change in the proportion of adherent patients between pre-admission and after discharge for all regularly scheduled long-term medications, using the proportion of days covered (PDC). Secondary endpoints included the change on mean PDC for all long-term medications, number of long-term medications, proportion of patients with hyperpolypharmacy, medication regimen complexity index (MRCI) score, drug burden index (DBI) score, number of potential inappropriate prescribing (PIP), and proportion of patients with ≥ 2 PIPs.
resultsNinety-three non-institutionalized patients were included (mean age 83.0 ± SD 6.1 years). The proportion of adherent patients increased from 22.1 to 51.9% (P < 0.001). Intervention also improved mean PDC [mean difference (95% CI) 10.6 (7.7, 13.5)] and effective prescribing through a reduction on the number of long-term medications [- 1.3 (- 1.7, - 0.9)], proportion of patients exposed to hyperpolypharmacy (- 16.1%, P < 0.001), MRCI score [- 2.2 (- 3.4, - 1.0)], DBI score [- 0.16 (- 1.8, - 1.3)], number of PIPs [- 1.6 (- 1.8, - 1.3)], and proportion of patients with ≥ 2 PIPs (- 53.7%, P < 0.001).
conclusionStudied intervention provides significant effective prescribing and medication adherence enhancements in non-institutionalized older patients with multimorbidity and polypharmacy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.