ArticleThe Journal of clinical endocrinology and metabolism2022
U-shaped Association Between Dietary Zinc Intake and New-onset Diabetes: A Nationwide Cohort Study in China.
Article in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 27 citations in OpenAlex.
- Zinc, type 2 diabetes, diabetic kidney disease: focus on hypoxia.Frontiers in endocrinology · 2026Review
- Sex-Specific Association Between Serum Zinc Concentration and Risk of Developing Type 2 Diabetes in Individuals with Isolated Impaired Fasting Glucose: A Prospective Cohort.Biological trace element research · 2025Article
- High Serum Zinc Concentration Accelerates Progression of Isolated Impaired Glucose Tolerance to Type 2 Diabetes: A Cohort Study.Biological trace element research · 2025Article
- Research progress of hypoxia-inducible factor-1α and zinc in the mechanism of diabetic kidney disease.Frontiers in pharmacology · 2025Review
- Association between dietary multi-metal intake and the risk of diabetic retinopathy: a population-based study.Frontiers in nutrition · 2025Article
- Association Between Dietary Antioxidant Quality Score (DAQS) and All-Cause Mortality in Hypertensive Adults: A Retrospective Cohort Study from the NHANES Database.Biological trace element research · 2024Article
- Diabetic cardiomyopathy - Zinc preventive and therapeutic potentials by its anti-oxidative stress and sensitizing insulin signaling pathways.Toxicology and applied pharmacology · 2023Review
- The association between plasma zinc concentrations and markers of glucose metabolism in adults in Cameroon.The British journal of nutrition · 2023Article
- Association of Dietary Intake of Zinc and Selenium with Breast Cancer Risk: A Case-Control Study in Chinese Women.Nutrients · 2023Article
- Dietary vitamin E intake and new-onset hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Association between Micronutrients and Hyperhomocysteinemia: A Case-Control Study in Northeast China.Nutrients · 2023Article
- Variety and quantity of dietary insoluble fiber intake from different sources and risk of new-onset hypertension.BMC medicine · 2023Article
- J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study in China.Frontiers of medicine · 2023Article
- Inflection Points in Blood Pressure Trajectories Preceding Hypertension Onset in Different Age Groups.Journal of the American Heart Association · 2023Article
- High Dietary Zinc Intake Is Associated with Shorter Leukocyte Telomere Length, Mediated by Tumor Necrosis Factor-α: A Study of China Adults.The journal of nutrition, health & aging · 2023Article
- Variety and Quantity of Dietary-Insoluble Fiber Intake From Different Sources and Risk of New-Onset Diabetes.The Journal of clinical endocrinology and metabolism · 2022Article
- Response to Letter to the Editor From Pattan et al: "U-shaped Association Between Dietary Zinc Intake and New-onset Diabetes: A Nationwide Cohort Study in China".The Journal of clinical endocrinology and metabolism · 2022Article
- U-shaped Association Between Dietary Zinc Intake and New-onset Diabetes: A Nationwide Cohort Study in China.The Journal of clinical endocrinology and metabolism · 2022Article
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9 authors at 2 institutions in 2 countries.
Funding
Abstract
aimsWe aimed to investigate the relationship of dietary zinc intake with new-onset diabetes among Chinese adults. MATERIALS AND
methodsA total of 16 257 participants who were free of diabetes at baseline from the China Health and Nutrition Survey were included. Dietary intake was measured by 3 consecutive 24-hour dietary recalls combined with a household food inventory. Participants with self-reported physician-diagnosed diabetes, or fasting glucose ≥ 7.0 mmol/L, or glycated hemoglobin ≥ 6.5% during the follow-up were defined as having new-onset diabetes.
resultsA total of 1097 participants developed new-onset diabetes during a median follow-up duration of 9.0 years. Overall, the association between dietary zinc intake and new-onset diabetes followed a U-shape (P for nonlinearity < 0.001). The risk of new-onset diabetes was significantly lower in participants with zinc intake < 9.1 mg/day (per mg/day: hazard ratio [HR], 0.73; 95% CI, 0.60-0.88), and higher in those with zinc intake ≥ 9.1 mg/day (per mg/day: HR, 1.10; 95% CI, 1.07-1.13). Consistently, when dietary zinc intake was assessed as deciles, compared with those in deciles 2-8 (8.9 -<12.2 mg/day), the risk of new-onset diabetes was higher for decile 1 (<8.9 mg/day: HR, 1.29; 95% CI, 1.04-1.62), and deciles 9 to 10 (≥12.2 mg/day: HR, 1.62; 95% CI, 1.38-1.90). Similar U-shaped relations were found for plant-derived or animal-derived zinc intake with new-onset diabetes (all P for nonlinearity < 0.001).
conclusionsThere was a U-shaped association between dietary zinc intake and new-onset diabetes in general Chinese adults, with an inflection point at about 9.1 mg/day.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.