Evidence map›Paper›PMID 34448483›Full record

ArticleFamily practice2021

Self-reported symptoms in French primary care SARS-CoV-2 patients: association with gender and age group.

Paul Sebo, Hubert Maisonneuve, Julie Lourdaux, Clara Cuzin, Martin Floquet, Benoit Tudrej, Dagmar M Haller

Open access · bronzeAbstract read
In one paragraph

Article in Family practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Paul SeboPrimary Care Unit, Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0001-7616-0017
Hubert MaisonneuvePrimary Care Unit, Faculty of Medicine, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-5276-1122
Julie LourdauxCerballiance Rhône-Alpes Laboratory, Lyon, France.
Clara CuzinUniversity College of General Medicine, University Claude Bernard Lyon 1.
Martin FloquetUniversity College of General Medicine, University Claude Bernard Lyon 1.
Benoit TudrejUniversity College of General Medicine, University Claude Bernard Lyon 1.
Dagmar M HallerPrimary Care Unit, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Université Claude Bernard Lyon 1 · FRUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe early identification of COVID-19 patients is of outmost importance in the current pandemic. As with other pathogens, presenting symptoms of SARS-CoV-2 may vary, depending on sociodemographic factors. We aimed to describe the clinical characteristics of COVID-19 patients by age/gender and to assess whether the diagnostic performance of these symptoms varied according to these variables.

methodsWe analysed data from a cross-sectional study involving primary care patients undergoing RT-PCR testing in Lyon, France. Among patients who tested positive, we examined whether there was an association between age/gender and various symptoms. In addition, we calculated the diagnostic performance of the most specific symptoms (smell/taste disorder).

resultsAmong 1543 consecutive patients, 253 tested positive (16%). There were significant age/gender-related differences in symptoms. In middle-aged women, the diagnostic performance of smell/taste disorders were AUC = 0.65 [95%CI 0.59-0.71] and PPV = 72% [95%CI 53-87%], that is higher than in the entire sample (smell/taste disorders: AUC = 0.59 [95%CI 0.57-0.62] and PPV = 57% [95%CI 47-67%]. In contrast, the negative predictive values of smell/taste disorders were similar in both groups (85% [95%CI 81-89%] for middle-age women and 86% [95%CI 85-88%] for the entire sample).

conclusionWe found significant age/gender-related differences in the clinical characteristics of COVID-19 patients. Screening strategies based on smell/taste disorders performed better in middle-aged women, but could not ensure a diagnosis of COVID-19 in any subgroup of patients. Future diagnostic strategies should use age/gender differentiated approaches.

Indexed as

Primary Health CareSelf ReportAdultAgedAge FactorsCOVID-19Cross-Sectional StudiesFemaleFranceHumansMaleMiddle AgedOlfaction DisordersPandemicsSARS-CoV-2Sex FactorsAgeCOVID-19Francegenderprimary caresymptoms

Identifiers

PMID34448483
PMCPMC8513396
OpenAlexW3196212379

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.