Evidence map›Paper›PMID 34448470›Full record

Observational studyInternational journal of occupational medicine and environmental health2022

The seroprevalence of the hepatitis B virus in Italian medical students after 3 decades since the introduction of universal vaccination.

Pietro Sartorelli, Federico Occhialini, Rosalia Miceli, Antonella Pietronigro, Laura Bianciardi, Chiara Salini, Gabriele Messina

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of occupational medicine and environmental health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06901362 (Seroprevalence and Vaccination Rate of Hepatitis B Virus and Varicella-zoster Virus Among Medical Students Under Immunizing Program), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06901362 completednot on this mapstarted 2025, after this paper: background citation

Seroprevalence and Vaccination Rate of Hepatitis B Virus and Varicella-zoster Virus Among Medical Students Under Immunizing Program

TypeobservationalSponsorThammasat UniversityRan2025 to 2025Enrolled401ConditionsHealthy, Healthy Adult
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Pietro SartorelliUniversity of Siena, Siena, Italy (Department of Medical Biotechnology, Unit of Occupational Health Azienda Ospedaliera Universitaria Senese).
Federico OcchialiniUniversity of Siena, Siena, Italy (Department of Medical Biotechnology).
Rosalia MiceliUniversity of Siena, Siena, Italy (Postgraduate School of Occupational Medicine).
Antonella PietronigroUniversity of Siena, Siena, Italy (Postgraduate School of Occupational Medicine).
Laura BianciardiUniversity of Siena, Siena, Italy (Department of Medical Biotechnology).
Chiara SaliniUniversity of Siena, Siena, Italy (Postgraduate School of Public Health).
Gabriele MessinaUniversity of Siena, Siena, Italy (Department of Molecular and Developmental Medicine).
Azienda Ospedaliera Universitaria Senese · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSince 1991 hepatitis B vaccination has been mandatory for all newborns in Italy. The aim of the study was to verify the long-term seroprevalence and the efficacy of hepatitis B vaccination in medical students of the University of Siena. MATERIAL AND

methodsA cross-sectional observational study was conducted on a population of 850 medical students of the University of Siena (322 males and 528 females, mean age: 23 years) by obtaining from the medical reports the serological analysis data for the total anti-hepatitis B antibodies (HBsAb) and information on hepatitis B vaccination (number of vaccine doses, age at the first vaccination, time since the final vaccination dose, country of origin). Raw odds ratios (ORs) and 95% confidence intervals (CIs) were initially calculated to evaluate the association between 2 variables. The adjusted ORs were then calculated using a multivariate logistic regression model to study the association between the variables and the possible confounding factors.

resultsOverall, 593 students (69.76%) were immunized against hepatitis B, while 257 (30.24%) had HBsAb antibody titer <10 mIU/ml. From the OR calculation, an inverse correlation emerged between seropositivity to hepatitis B and age, and between seropositivity to hepatitis B and the age at the first vaccination dose. There was also a correlation between seropositivity and the number of vaccination doses received. By performing the multivariate logistic analysis, correlations with these variables were confirmed.

conclusionsA significant part of the studied population was not immunized against hepatitis B virus, despite the fact that vaccination had been carried out as prescribed by law. The results of the study reaffirm the importance of health surveillance in subjects at biological risk such as medical students. Int J Occup Med Environ Health. 2022;35(1):75-80.

Indexed as

Hepatitis BStudents, MedicalAdultCross-Sectional StudiesFemaleHepatitis B AntibodiesHepatitis B Surface AntigensHepatitis B VaccinesHepatitis B virusHumansInfant, NewbornItalyMaleSeroepidemiologic StudiesVaccinationYoung AdultHepatitis B AntibodiesHepatitis B Surface AntigensHepatitis B Vaccineshepatitis Bhepatitis B antibodiesimmunizationmedical studentsseroepidemiological studiesvaccination

Identifiers

PMID34448470
PMCPMC10464808
OpenAlexW3195275203

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.