Evidence map›Paper›PMID 34448248›Full record

ReviewPediatric dermatology2021

CARD14-associated papulosquamous eruption (CAPE) in pediatric patients: Three additional cases and review of the literature.

Cindy P Frare, Alli J Blumstein, Amy S Paller, Lia Pieretti, Keith A Choate, Anne M Bowcock, Margarita Larralde

Open access · greenAbstract readCase ReportsReview
In one paragraph

Review in Pediatric dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. HomozygousBMJ case reports · 2024
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. [Psoriasis in children and adolescents].Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde · 2023
    Review
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Cindy P FrareDepartment of Dermatology, Hospital Alemán, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0001-8488-5675
Alli J BlumsteinDepartments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Amy S PallerDepartments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID https://orcid.org/0000-0001-6187-6549
Lia PierettiDr Úraga Private Center for Skin Diseases, Guayaquil, Ecuador.
Keith A ChoateDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.
Anne M BowcockDermatology, Oncological Sciences and Genetics & Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Margarita LarraldeDepartment of Dermatology, Hospital Alemán, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0002-3801-194X
Northwestern University · USHospital Alemán · ARHospital Ramos Mejía · ARIcahn School of Medicine at Mount Sinai · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Center for Mendelian DisordersU54HG006504 · NHGRI · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, GUNEL, MURAT · 2012 to 2015
$11.0M
Genome-Wide SNP Association in PsoriasisR01AR050266 · NIAMS · WASHINGTON UNIVERSITY · PI BOWCOCK, ANNE MARY · 2007 to 2016
$5.7M
Genetics and Pathobiology of Disorders of KeratinizationR01AR068392 · NIAMS · YALE UNIVERSITY · PI KEITH A CHOATE · 2015 to 2026
$5.7M
Foundation for Ichthyosis and Related Skin TypesNCATS NIH HHS UL1 TR001863NHGRI NIH HHS U54 HG006504NIAMS NIH HHS R01 AR050266NIAMS NIH HHS R01 AR068392NIH HHS R01 AR050266NIH HHS R01 AR068392
6 · The paper itself

Abstract

CARD14-associated papulosquamous eruption (CAPE) is a proposed term that encompasses features ranging from psoriasis to pityriasis rubra pilaris (PRP) in association with CARD14 mutations. The early onset of the disease, prominent facial involvement, family history of an autosomal dominant trait, and poor response to conventional treatment are characteristics of CAPE that distinguish it from classical psoriasis and PRP. We describe the clinical features, family history, and response to therapy in three unrelated children with CAPE and compare these characteristics with those of previously described pediatric patients. Testing for CARD14 mutations in children with early onset of features of psoriasis or pityriasis rubra pilaris and resistance to conventional therapy should be considered.

Indexed as

ExanthemaPityriasis Rubra PilarisCARD Signaling Adaptor ProteinsChildGuanylate CyclaseHumansMembrane ProteinsCARD14 protein, humanCARD Signaling Adaptor ProteinsGuanylate CyclaseMembrane ProteinsCARD14childpityriasis rubra pilarispsoriasisustekinumab

Identifiers

PMID34448248
PMCPMC8578307
OpenAlexW3193430753

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.