Evidence map›Paper›PMID 34448096›Full record

ReviewBiotechnology letters2021

The application of oncolytic viruses in cancer therapy.

Yang Gao, Yan Wu, Tian Huan, Xiaoyan Wang, Jun Xu, Qinggang Xu, Feng Yu, Haifeng Shi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Biotechnology letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Viruses: Friends or foes.Microbial biotechnology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yang GaoSchool of Life Sciences, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, People's Republic of China.
Yan WuSchool of Life Sciences, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, People's Republic of China.
Tian HuanSchool of Life Sciences, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, People's Republic of China.
Xiaoyan WangDepartment of Gastroenterology, The First People's Hospital of Suqian, Suqian, Jiangsu, People's Republic of China.
Jun XuDepartment of Cognitive Neurology, China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing Tian Tan Hospital, Affiliated to Capital Medical University, Beijing, People's Republic of China.
Qinggang XuSchool of Life Sciences, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, People's Republic of China.
Feng YuSchool of Life Sciences, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, People's Republic of China. yufeng@ujs.educn.ORCID http://orcid.org/0000-0002-1929-3881
Haifeng ShiSchool of Life Sciences, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, People's Republic of China. shihf@ujs.educn.
Jiangsu University · CNCapital Medical University · CN

Funding

National Natural Science Foundation of China 81870821National Natural Science Foundation of China 82071187Natural Science Foundation of Jiangsu Province BK20151347
6 · The paper itself

Abstract

Oncolytic therapy is a treatment method used to directly combat tumor cells by modifying the genes of naturally occurring low pathogenic viruses to form "rhizobia" virus. By taking the advantage of abnormal signal pathways in cancer cells, it selectively replicates in tumor cells leading to tumor cell lysis and death. At present, clinical studies widely employ biomolecular technology to transform oncolytic viruses to exert stronger oncolytic effects and reduce their adverse reactions. This review summarizes the current progresses and the molecular mechanism of oncolytic viruses towards tumor treatment and management.

Indexed as

Oncolytic VirotherapyOncolytic VirusesAnimalsHumansMiceNeoplasmsCancer therapyImmune responseMolecular mechanismOncolytic virus

Identifiers

PMID34448096
OpenAlexW3196085158

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.