Evidence map›Paper›PMID 34448087›Full record

ArticleJournal of clinical immunology2021

Hematopoietic Cell Transplantation for Severe Combined Immunodeficiency Patients: a Japanese Retrospective Study.

Satoshi Miyamoto, Katsutsugu Umeda, Mio Kurata, Akira Nishimura, Masakatsu Yanagimachi, Masataka Ishimura, Maho Sato, Tomonari Shigemura, Motohiro Kato, Yoji Sasahara and 11 more

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In one paragraph

Article in Journal of clinical immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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  19. Endocrinopathies in Inborn Errors of Immunity.Frontiers in immunology · 2021
    Review
  20. Centralized rapid genetic diagnosis of combined immunodeficiency in Japan.Pediatrics international : official journal of the Japan Pediatric Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 15 institutions in 1 country.

Satoshi MiyamotoDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan.
Katsutsugu UmedaHereditary Disorder Working Group of the Japanese Society for Transplantation and Cellular Therapy, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi, Japan.
Mio KurataJapanese Data Center for Hematopoietic Cell Transplantation, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi, Japan.
Akira NishimuraDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan.
Masakatsu YanagimachiHereditary Disorder Working Group of the Japanese Society for Transplantation and Cellular Therapy, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi, Japan.
Masataka IshimuraDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan.
Maho SatoDepartment of Hematology/Oncology, Osaka Women's and Children's Hospital, 840 Murodocho, Izumi, Osaka, Japan.
Tomonari ShigemuraDepartment of Pediatrics, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, Japan.
Motohiro KatoChildren's Cancer Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, Japan.
Yoji SasaharaHereditary Disorder Working Group of the Japanese Society for Transplantation and Cellular Therapy, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi, Japan.
Akihiro IguchiHereditary Disorder Working Group of the Japanese Society for Transplantation and Cellular Therapy, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi, Japan.
Takashi KoikeDepartment of Pediatrics, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, Japan.
Yoshiyuki TakahashiDepartment of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showa-ku, Nagoya, Aichi, Japan.
Michiko KajiwaraCenter for Transfusion Medicine and Cell Therapy, Tokyo Medical and Dental University, Medical Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan.
Masami InoueDepartment of Hematology/Oncology, Osaka Women's and Children's Hospital, 840 Murodocho, Izumi, Osaka, Japan.
Yoshiko HashiiDepartment of Cancer Immunotherapy, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, 2-15, Japan.
Hiromasa YabeHereditary Disorder Working Group of the Japanese Society for Transplantation and Cellular Therapy, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi, Japan.
Koji KatoHereditary Disorder Working Group of the Japanese Society for Transplantation and Cellular Therapy, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi, Japan.
Yoshiko AtsutaJapanese Data Center for Hematopoietic Cell Transplantation, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi, Japan.
Kohsuke ImaiHereditary Disorder Working Group of the Japanese Society for Transplantation and Cellular Therapy, 1-1-20 Daiko-Minami, Higashi-ku, Nagoya, Aichi, Japan. kimai.ped@tmd.ac.jp.ORCID http://orcid.org/0000-0003-2132-8403
Tomohiro MorioDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan.
Tokyo Medical and Dental University · JPOsaka Women's and Children's Hospital · JPTokai University · JPAichi Medical University · JPHokkaido University Hospital · JPJapanese Red Cross Society, Japan · JPKanagawa Children's Medical Center · JPKyoto University · JPKyushu University · JPNagoya University · JPNational Center For Child Health and Development · JPShinshu University · JPThe Japanese Data Center for Hematopoietic Cell Transplantation · JPThe University of Osaka · JPTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHematopoietic cell transplantation (HCT) is a curative therapy for patients with severe combined immunodeficiency (SCID). Here, we conducted a nationwide study to assess the outcome of SCID patients after HCT in Japan.

methodsA cohort of 181 SCID patients undergoing their first allogeneic HCT in 1974-2016 was studied by using the Japanese national database (Transplant Registry Unified Management Program, TRUMP).

resultsThe 10-year overall survival (OS) of the patients who received HCT in 2006-2016 was 67%. Umbilical cord blood (UCB) transplantation was performed in 81 patients (45%). The outcomes of HCT from HLA-matched UCB (n = 21) and matched sibling donors (n = 22) were comparable, including 10-year OS (91% vs. 91%), neutrophil recovery (cumulative incidence at 30 days, 89% vs. 100%), and platelet recovery (cumulative incidence at 60 days, 89% vs. 100%). Multivariate analysis of the patients who received HCT in 2006-2016 demonstrated that the following factors were associated with poor OS: bacterial or fungal infection at HCT (hazard ratio (HR): 3.8, P = 0.006), cytomegalovirus infection prior to HCT (HR: 9.4, P = 0.03), ≥ 4 months of age at HCT (HR: 25.5, P = 0.009), and mismatched UCB (HR: 19.8, P = 0.01).

conclusionWe showed the potential of HLA-matched UCB as a donor source with higher priority for SCID patients. We also demonstrated that early age at HCT without active infection is critical for a better prognosis, highlighting the importance of newborn screening for SCID.

Indexed as

Cord Blood Stem Cell TransplantationHematopoietic Stem Cell TransplantationAdolescentChildChild, PreschoolFemaleGraft vs Host DiseaseHumansInfantJapanKaplan-Meier EstimateMaleRetrospective StudiesSevere Combined ImmunodeficiencyCord blood transplantationHematopoietic cell transplantationJapanNewborn screeningRetrospective studySevere combined immunodeficiency

Identifiers

PMID34448087
PMCPMC8390179
OpenAlexW3195776781

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.