ArticleClinical oral investigations2022
The clinical association between Periodontitis and COVID-19.
Article in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05950230 (A Case-Control Study on the Association Between Periodontal Health and Gingival Crevicular Level of Matrix Metalloproteinase-8 in Post COVID-19 Patients), which is not on this map. Cited by 50 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Case-Control Study on the Association Between Periodontal Health and Gingival Crevicular Level of Matrix Metalloproteinase-8 in Post COVID-19 Patients
Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- The impact of periodontal disease on the clinical outcomes of COVID-19: A systematic review and meta-analysis.BMC oral health · 2023Pooled it
- Prevalence, Features and Degree of Association of Oral Lesions in COVID-19: A Systematic Review of Systematic Reviews.International journal of environmental research and public health · 2022Pooled it
- Oral Health Implications of SARS-CoV-2/COVID-19: A Systematic Review.Oral health & preventive dentistry · 2022Pooled it
- Periodontitis and all-cause mortality in 60- and 66-year-old individuals: a 23-year prospective cohort study.Acta odontologica Scandinavica · 2026Article
- Estimating the Causal Effect of Tooth Loss on the Critical Outcome of COVID-19.JDR clinical and translational research · 2026Article
- Diagnostic accuracy of aMMP-8 levels in oral biofluids for monitoring periodontitis in patients with metabolic syndrome.Clinical oral investigations · 2025Article
- Current Landscape of the Interrelationship Between Periodontitis, Type 2 Diabetes Mellitus, and COVID-19.International journal of molecular sciences · 2025Review
- Association Between Periodontitis and SARS-CoV-2 Infection Severity: A Cross-Sectional Study in a Turkish Population.Oral health & preventive dentistry · 2025Article
- Relationship Between Periodontitis and the Severity of Lung Infection Caused by COVID-19: A Case-Control Observational Study.Health science reports · 2025Article
- The effect of text message-based health guidelines reinforcement on clinical outcomes following non-surgical periodontal therapy: A randomized clinical trial.Journal of education and health promotion · 2025Article
- Interdisciplinary research on periodontitis and depression: a bibliometric analysis of research trends, hotspots and future directions.Frontiers in oral health · 2025Article
- Relationship between periodontitis, type 2 diabetes mellitus and COVID-19 disease: a narrative review.Frontiers in cellular and infection microbiology · 2025Review
- Influence of Type of Dental Visit on the Incidence of COVID-19 and Related Hospitalisation Among Older People in Japan.International journal of environmental research and public health · 2024Article
- The role of viruses in oral mucosal lesions.Periodontology 2000 · 2024Review
- COVID-19 Severity in Patients With Apical Periodontitis: A Case Control Study.International dental journal · 2024Article
- Is There a Correlation Between Periodontal Disease Symptoms and the COVID-19 Vaccination?Cureus · 2024Article
- Advances in the relationship between periodontopathogens and respiratory diseases (Review).Molecular medicine reports · 2024Review
- QbD-Assisted Development and Optimization of Doxycycline Hyclate- and Hydroxyapatite-Loaded Nanoparticles for Periodontal Delivery.ACS omega · 2024Article
- Proposed Mechanisms for the Relationship between Periodontal Diseases and the Severity of Covid-19: Common Pathogens, Inflammatory Mediators, and Risk Factors.Advanced biomedical research · 2024Review
- Clinical, immunological, and microbiological analysis of the association between periodontitis and COVID-19: a case-control study.Odontology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe study aimed to clinically assess the association between periodontitis and COVID-19-related outcomes. MATERIAL AND
methodsData pertaining to patient demographics, medical history, blood parameters, periodontal clinical examination and aMMP-8 point-of-care diagnostics (both site-level and patient-level) was recorded for eighty-two COVID-19-positive patients. COVID-19-related outcomes such as COVID-19 pneumonia, death/survival, types of hospital admission and need of assisted ventilation were also assessed.
resultsMales were predominantly afflicted with COVID-19, with advanced age exhibiting a greater association with the presence of periodontitis. Higher severity of periodontitis led to 7.45 odds of requiring assisted ventilation, 36.52 odds of hospital admission, 14.58 odds of being deceased and 4.42 odds of COVID-19-related pneumonia. The aMMP-8 mouthrinse kit was slightly more sensitive but less specific than aMMP-8 site-specific tests.
conclusionsBased on the findings of the present study, periodontitis seems to be related to poorer COVID-19-related outcomes. However, within the constraints of this work, a direct causality may not be established. Periodontitis, by means of skewing the systemic condition for a number of comorbidities, may eventually influence COVID-19 outcomes in an indirect manner. CLINICAL RELEVANCE: The study is the first to clinically, and by means of a validated point-of-care diagnostic methodology, assess the association between periodontal health and COVID-19-related outcomes. Assessment of the periodontal status of individuals can aid in the identification of risk groups during the pandemic along with reinforcing the need to maintain oral hygiene and seeking periodontal care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.