Evidence map›Paper›PMID 34448039›Full record

ArticleArchives of gynecology and obstetrics2022

Comprehensive characterization of endometriosis patients and disease patterns in a large clinical cohort.

Simon Blum, Peter A Fasching, Thomas Hildebrandt, Johannes Lermann, Felix Heindl, Tilman Born, Hannah Lubrich, Sophia Antoniadis, Karina Becker, Christine Fahlbusch and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of gynecology and obstetrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Clinical characterization of endometriosis phenotypes.Archives of gynecology and obstetrics · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Simon BlumDepartment of Gynecology and Obstetrics, University Endometriosis Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.ORCID 0000-0002-8935-5558
Peter A FaschingDepartment of Gynecology and Obstetrics, University Endometriosis Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.
Thomas HildebrandtDepartment of Gynecology and Obstetrics, University Endometriosis Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.
Johannes LermannDepartment of Gynecology and Obstetrics, University Endometriosis Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.
Felix HeindlDepartment of Gynecology and Obstetrics, University Endometriosis Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.
Tilman BornDepartment of Gynecology and Obstetrics, University Endometriosis Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.
Hannah LubrichDepartment of Gynecology and Obstetrics, University Endometriosis Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.
Sophia AntoniadisDepartment of Gynecology and Obstetrics, University Endometriosis Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.
Karina BeckerDepartment of Gynecology and Obstetrics, University Endometriosis Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.
Christine FahlbuschDepartment of Gynecology and Obstetrics, University Endometriosis Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.
Katharina HeusingerDepartment of Gynecology and Obstetrics, University Endometriosis Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.
Stefanie BurghausDepartment of Gynecology and Obstetrics, University Endometriosis Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.
Matthias W BeckmannDepartment of Gynecology and Obstetrics, University Endometriosis Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany.
Alexander HeinDepartment of Gynecology and Obstetrics, University Endometriosis Center for Franconia, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Universitätsstrasse 21-23, 91054, Erlangen, Germany. alexander.hein@uk-erlangen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn many diseases, it is possible to classify a heterogeneous group into subgroups relative to tumor biology, genetic variations, or clinical and pathological features. No such classification is available for endometriosis. In our retrospective case-case analysis we defined subgroups of endometriosis patients relative to the type and location of the endometriosis lesion and relative to basic patient characteristics.

methodsFrom June 2013 to July 2017, a total of 1576 patients with endometriosis diagnosed at surgery were included in this study. The patients' history and clinical data were documented using a web-based remote data entry system. To build subgroups, all possible combinations of endometriosis locations/types (peritoneal; ovarian endometriosis; deeply infiltrating endometriosis; adenomyosis) were used. Due to the variation in group sizes, they were combined into five substantial larger groups.

resultsAge, pregnancy rate, and live birth rate were identified as characteristics that significantly differed between the five patient groups that were defined. No significant differences were noted in relation to body mass index, length of menstrual cycle, age at menarche, reason for presentation, or educational level.

conclusionThis study describes basic patient characteristics in relation to common clinical subgroups in a large clinical cohort of endometriosis patients. Epidemiological information about different clinical groups may be helpful in identifying groups with specific clinical courses, potentially suggesting novel approaches to early detection and to surgical and systemic treatment.

Indexed as

AdenomyosisEndometriosisCohort StudiesFemaleHumansPregnancyPregnancy RateRetrospective StudiesCase–case analysisClassificationEndometriosis

Identifiers

PMID34448039
PMCPMC8967757

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.