Evidence map›Paper›PMID 34448008›Full record

SynthesisWorld journal of urology2022

What is the role of single-stage oral mucosa graft urethroplasty in the surgical management of lichen sclerosus-related stricture disease in men? A systematic review.

Francesco Esperto, Wesley Verla, Achilles Ploumidis, Rachel Barratt, Roberto La Rocca, Nicolaas Lumen, Yuhong Yuan, Felix Campos-Juanatey, Tamsin Greenwell, Francisco Martins and 4 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in World journal of urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 8 countries.

Francesco Esperto *Department of Urology, Campus Biomedico University of Rome, Via Álvaro Del Portillo, 200 00128, Rome, Italy. francescoesperto@gmail.com.
Wesley Verla *Division of Urology, Gent University Hospital, Gent, Belgium.
Achilles PloumidisDepartment of Urology, Athens Medical Centre, Athens, Greece.
Rachel BarrattDepartment of Urology, University College London Hospital, London, UK.
Roberto La RoccaDepartment of Urology, University of Naples Federico II, Naples, Italy.
Nicolaas LumenDivision of Urology, Gent University Hospital, Gent, Belgium.
Yuhong YuanDepartment of Medicine, Health Science Centre, McMaster University, Hamilton, ON, Canada.
Felix Campos-JuanateyUrology Department, Marques de Valdecilla University Hospital, Santander, Spain.
Tamsin GreenwellDepartment of Urology, University College London Hospital, London, UK.
Francisco MartinsDepartment of Urology, Santa Maria University Hospital, University of Lisbon, School of Medicine, Lisbon, Portugal.
Nadir OsmanDepartment of Urology, Sheffield Teaching Hospitals, Sheffield, UK.
Silke RiechardtDepartment of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Marjan WaterloosDivision of Urology, Gent University Hospital, Gent, Belgium.
Konstantinos DimitropoulosDepartment of Urology, Aberdeen Royal Infirmary, Aberdeen, Scotland, UK.
Ghent University Hospital · BEUniversity College London · GBAberdeen Royal Infirmary · GBAthens Medical Center · GRHospital de Santa Maria · PTMarqués de Valdecilla University Hospital · ESMcMaster University Medical Centre · CASheffield Teaching Hospitals NHS Foundation Trust · GBUniversità Campus Bio-Medico · ITUniversität Hamburg · DEUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe benefits and harms of the available types of surgical management for lichen sclerosus-related (LS) strictures remain unclear and, thus, clear and robust clinical practice recommendations cannot be given. MATERIALS AND

methodsTo assess the role of single-stage OMGU in the management of LS strictures and explore how its benefits and harms compare with the alternative management options. Medline, Embase and Cochrane controlled trial databases (CENTRAL, CDSR) were systematically searched. Randomized (RCTs) and nonrandomized studies (NRCSs) comparing single-stage OMGU with other surgical management options for LS strictures and single-arm studies on single-stage OMGU were included. Risk of bias (RoB) was assessed.

resultsOf the 1912 abstracts identified, 15 studies (1 NRCS and 14 single-arm studies) were included, recruiting in total 649 patients. All studies were at high RoB. In the only NRCS available, stricture-free rate (SFR) for single-stage and staged OMGU was 88% vs 60%, respectively (p = 0.05), at a mean follow-up of 66.5 months. SFR range for single-stage OMGU in single-arm studies was 65-100% (mean/median follow-up, 12-59 months). Single-stage OMGU had low complication rates and beneficial impact on LUTS and QoL.

conclusionsThe present SR highlights the methodological limitations of the available literature. In the absence of adverse local tissue conditions, and taking into consideration benefit-harm balance and surgeon's skills and expertise, single-stage OMGU can be justified in patients with LS strictures.

Indexed as

Lichen Sclerosus et AtrophicusUrethral StrictureConstriction, PathologicHumansMaleMouth MucosaQuality of LifeRetrospective StudiesTreatment OutcomeUrethraUrologic Surgical Procedures, MaleLichen sclerosus stricturesOral mucosa graft urethroplastyPanurethral stricture diseaseStricture management

Identifiers

PMID34448008
OpenAlexW3195832604

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.