Evidence map›Paper›PMID 34447971›Full record

ArticleFunctional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH (Conference)2021

Simultaneous Multi-Heartbeat ECGI Solution with a Time-Varying Forward Model: a Joint Inverse Formulation.

Jake A Bergquist, Jaume Coll-Font, Brian Zenger, Lindsay C Rupp, Wilson W Good, Dana H Brooks, Rob S MacLeod

Open access · greenAbstract read
In one paragraph

Article in Functional imaging and modeling of the heart : ... International Workshop, FIMH ..., proceedings. FIMH (Conference), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jake A BergquistBiomedical Engineering Department, University of Utah, SLC, UT, 84112, USA.ORCID 0000-0002-4586-6911
Jaume Coll-FontCardiovascular Bioengineering & Imaging Lab, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9341-6838
Brian ZengerBiomedical Engineering Department, University of Utah, SLC, UT, 84112, USA.ORCID 0000-0002-0039-9184
Lindsay C RuppBiomedical Engineering Department, University of Utah, SLC, UT, 84112, USA.ORCID 0000-0002-2688-7688
Wilson W GoodBiomedical Engineering Department, University of Utah, SLC, UT, 84112, USA.ORCID 0000-0002-0111-9076
Dana H BrooksDepartment of Electrical and Computer Engineering, Northeastern University, Boston, MA, USA.ORCID 2222-3333-4444-5555
Rob S MacLeodBiomedical Engineering Department, University of Utah, SLC, UT, 84112, USA.ORCID 0000-0002-0000-0356
University of Utah · USHarvard University · USNortheastern University · US

Funding

TRD - VisualizationP41GM103545 · NIGMS · UNIVERSITY OF UTAH · PI MACLEOD, ROB S. · 2012 to 2019
$9.7M
Center for Integrative Biomedical Computing Legacy TransitionR24GM136986 · NIGMS · UNIVERSITY OF UTAH · PI JOHNSON, CHRISTOPHER R., MACLEOD, ROB S. · 2020 to 2022
$1.6M
Novel Characterization and Detection Techniques for Acute Myocardial IschemiaF30HL149327 · NHLBI · UNIVERSITY OF UTAH · PI ZENGER, BRIAN · 2020 to 2022
$117k
NHLBI NIH HHS F30 HL149327NIGMS NIH HHS P41 GM103545NIGMS NIH HHS R24 GM136986
6 · The paper itself

Abstract

Electrocardiographic imaging (ECGI) is an effective tool for noninvasive diagnosis of a range of cardiac dysfunctions. ECGI leverages a model of how cardiac bioelectric sources appear on the torso surface (the forward problem) and uses recorded body surface potential signals to reconstruct the bioelectric source (the inverse problem). Solutions to the inverse problem are sensitive to noise and variations in the body surface potential (BSP) recordings such as those caused by changes or errors in cardiac position. Techniques such as signal averaging seek to improve ECGI solutions by incorporating BSP signals from multiple heartbeats into an averaged BSP with a higher SNR to use when estimating the cardiac bioelectric source. However, signal averaging is limited when it comes to addressing sources of BSP variability such as beat to beat differences in the forward solution. We present a novel joint inverse formulation to solve for the cardiac source given multiple BSP recordings and known changes in the forward solution, here changes in the heart position. We report improved ECGI accuracy over signal averaging and averaged individual inverse solutions using this joint inverse formulation across multiple activation sequence types and regularization techniques with measured canine data and simulated heart motion. Our joint inverse formulation builds upon established techniques and consequently can easily be applied with many existing regularization techniques, source models, and forward problem formulations.

Indexed as

Electrocardiographic ImagingInverse ProblemsSignal Averaging

Identifiers

PMID34447971
PMCPMC8385662
OpenAlexW3176276800

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.