Evidence map›Paper›PMID 34447902›Full record

ArticleContact (Thousand Oaks (Ventura County, Calif.))2021

"VTT"-domain proteins VMP1 and TMEM41B function in lipid homeostasis globally and locally as ER scramblases.

Karin M Reinisch, Xiao-Wei Chen, Thomas J Melia

Abstract read
In one paragraph

Article in Contact (Thousand Oaks (Ventura County, Calif.)), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Lipid Scrambling Pathways in the Sec61 Translocon Complex.Journal of the American Chemical Society · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Karin M ReinischDepartment of Cell Biology, Yale School of Medicine, New Haven, CT 06520.
Xiao-Wei ChenState Key Laboratory of Membrane Biology, College of Future Technology, Center for Life Sciences, Peking University, Beijing, 100871.
Thomas J MeliaDepartment of Cell Biology, Yale School of Medicine, New Haven, CT 06520.

Funding

Molecular Basis for Membrane Lipid HomeostasisR35GM131715 · NIGMS · YALE UNIVERSITY · PI KARIN M REINISCH · 2019 to 2026
$6.5M
Lipid flux during autophagosome membrane biogenesisR01GM135290 · NIGMS · YALE UNIVERSITY · PI MELIA, THOMAS JAMES · 2020 to 2023
$1.3M
NIGMS NIH HHS R01 GM135290NIGMS NIH HHS R35 GM131715
6 · The paper itself

Abstract

Recent studies have identified the metazoan ER-resident proteins, TMEM41B and VMP1, and so structurally related VTT-domain proteins, as glycerolipid scramblases.

Identifiers

PMID34447902
PMCPMC8386813

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.