Evidence map›Paper›PMID 34447814›Full record

ReviewWorld journal of clinical cases2021

Acute acalculous cholecystitis due to infectious causes.

Ioulia Markaki, Afroditi Konsoula, Lamprini Markaki, Nikolaos Spernovasilis, Marios Papadakis

Abstract readReview
In one paragraph

Review in World journal of clinical cases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Man with right periumbilical pain.Journal of the American College of Emergency Physicians open · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ioulia MarkakiDepartment of Emergency, General Hospital of Kythira "Trifyllio", Kythira 80200, Greece.
Afroditi KonsoulaDepartment of Emergency, General Hospital of Mytilene "Vostaneio", Lesvos 81132, Greece.
Lamprini MarkakiDepartment of Pediatrics, "Agia Sofia" Children's Hospital, Athens 11527, Greece.
Nikolaos SpernovasilisSchool of Medicine, University of Crete, Heraklion 71003, Greece.
Marios PapadakisDepartment of Surgery II, University of Witten-Herdecke, Wuppertal 40235, NRW, Germany. marios_papadakis@yahoo.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute acalculous cholecystitis (AAC) is an inflammation of the gallbladder not associated with the presence of gallstones. It usually occurs in critically ill patients but it has also been implicated as a cause of cholecystitis in previously healthy individuals. In this subgroup of patients, infectious causes comprise the primary etiology. We, herein, discuss the pathophysiological mechanisms involved in AAC, focusing on the infectious causes. AAC associated with critical medical conditions is caused by bile stasis and gallbladder ischemia. Several mechanisms are reported to be involved in AAC in patients without underlying critical illness including direct invasion of the gallbladder epithelial cells, gallbladder vasculitis, obstruction of the biliary tree, and sequestration. We emphasize that multiple pathogenic mechanisms may concurrently contribute to the development of AAC in varying degrees. Awareness of the implicated pathogens is essential since it will allow a more focused examination of the histopathological specimens. In conclusion, additional research and a high degree of clinical suspicion are needed to clarify the complex spectrum of mechanisms that are involved in the pathogenesis of AAC.

Indexed as

CholecystitisEpstein-Barr virusInfectious causesSequestrationVasculitis

Identifiers

PMID34447814
PMCPMC8362504

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.