Evidence map›Paper›PMID 34447751›Full record

ArticleFrontiers in cell and developmental biology2021

Differential Expression Profiles and Function Predictions for tRFs & tiRNAs in Skin Injury Induced by Ultraviolet Irradiation.

Yuan Fang, Yang Liu, Yu Yan, Yiyu Shen, Zenan Li, Xu Li, Yufang Zhang, Zhigang Xue, Cong Peng, Xiang Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Transfer RNA Fragments in Diseases of Sensory Organs.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuan FangDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.
Yang LiuDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.
Yu YanDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, China.
Yiyu ShenDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.
Zenan LiDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.
Xu LiDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.
Yufang ZhangAnyang Tumor Hospital, The Fourth Affiliated Hospital of Henan University of Science and Technology, Anyang, China.
Zhigang XueTongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Cong PengHunan Engineering Research Center of Skin Health and Disease, Changsha, China.
Xiang ChenHunan Engineering Research Center of Skin Health and Disease, Changsha, China.
Ke CaoDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.
Jianda ZhouDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultraviolet (UV) radiation is a major environmental factor contributing skin damage. As UV exposure is inevitable, it is necessary to pay attention to the underlying molecular mechanisms of UV-induced skin damage to develop effective therapies. tRNA-derived stress-induced RNAs (tiRNAs) and tRNA-derived fragments (tRFs) are tRNA-derived small RNAs (tsRNAs) that are a novel class of short, non-coding RNAs. However, the functions behind tRFs & tiRNAs in UV-induced skin injury are not yet clear. Firstly, the animal model of ultraviolet irradiation induced skin damage was established. Then the skin samples were preserved for the follow-up experiment. Sequencing was used to screen expression profiles and predict target genes. Compared with normal skin, a total of 31 differentially expressed tRFs & tiRNAs were screened. Among these, 10 tRFs & tiRNAs were shown to be significantly different in expression levels, where there were 4 up-regulated and 6 down-regulated target genes. Bioinformatics analyses revealed potential up-regulated tsRNAs (tRF-Val-AAC-012, tRF-Pro-AGG-012, tRF-Val-CAC-018, tRF-Val-AAC-031) and down-regulated tsRNAs (tRF-Arg-CCT-002, tRF-Trp-TCA-001, tiRNA-Ser-GCT-001, tRF-Gly-CCC-019, tRF-Ala-TGC-001, tRF-Ala-TGC-002). In summary, it was speculated that tRF-Gly-CCC-019 plays an important role in acute skin injury induced by UVB radiation by regulating the ras-related C3 botulinum toxin substrate 1 (Rac1) gene in the WNT signaling pathway. This study provides new insights into the mechanisms and therapeutic targets of UV-induced skin injury.

Indexed as

bioinformaticssequencingskin injurytRF & tiRNAultraviolet irradiation

Identifiers

PMID34447751
PMCPMC8383935

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.