Evidence map›Paper›PMID 34447699›Full record

ArticleFrontiers in cellular and infection microbiology2021

An Extracellular Redox Signal Triggers Calcium Release and Impacts the Asexual Development of

Eduardo Alves, Henry J Benns, Lilian Magnus, Caia Dominicus, Tamás Dobai, Joshua Blight, Ceire J Wincott, Matthew A Child

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Cysteine-S-nitrosylation inhibits Rop5-mediated immune evasion inbioRxiv : the preprint server for biology · 2025
    Article
  3. Low Tenacity ofMicroorganisms · 2025
    Article
  4. Article
  5. Metabolic changes to host cells withbioRxiv : the preprint server for biology · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Recombinant actin-depolymerizing factor of the apicomplexanFrontiers in cellular and infection microbiology · 2022
    Article
  11. The Redox Homeostasis of Skeletal Muscle Cells Regulates Stage Differentiation ofFrontiers in cellular and infection microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Eduardo AlvesDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Henry J BennsDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Lilian MagnusDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Caia DominicusSignaling in Apicomplexan Parasites Laboratory, The Francis Crick Institute, London, United Kingdom.
Tamás DobaiDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Joshua BlightDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Ceire J WincottDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Matthew A ChildDepartment of Life Sciences, Imperial College London, London, United Kingdom.
Imperial College London · GBThe Francis Crick Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M011178/1Wellcome TrustWellcome Trust 202553/Z/16/Z
6 · The paper itself

Abstract

The ability of an organism to sense and respond to environmental redox fluctuations relies on a signaling network that is incompletely understood in apicomplexan parasites such as

Indexed as

ToxoplasmaCalciumCalcium SignalingHumansHydrogen PeroxideOxidation-ReductionCalciumHydrogen Peroxidecalciumegressredoxsignalingtoxoplasma

Identifiers

PMID34447699
PMCPMC8382974
OpenAlexW3187619424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.