Evidence map›Paper›PMID 34447692›Full record

ArticleFrontiers in oncology2021

The Correlation Between Potential "Anti- Cancer" Trace Elements and the Risk of Breast Cancer: A Case-Control Study in a Chinese Population.

Heng Xue, Rui Qiao, Lailai Yan, Siyu Yang, Yongming Liang, Yaqiong Liu, Qing Xie, Ligang Cui, Bing Cao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Heng XueDepartment of Ultrasound, Peking University Third Hospital, Beijing, China.
Rui QiaoBaotou Medical College, Inner Mongolia University of Science and Technology, Baotou, China.
Lailai YanDepartment of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, China.
Siyu YangTianjin Center for Disease Control and Prevention, Tianjin, China.
Yongming LiangDepartment of Laboratory Medicine, Peking University Third Hospital, Beijing, China.
Yaqiong LiuDepartment of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, China.
Qing XieDepartment of Laboratorial Science and Technology, School of Public Health, Peking University, Beijing, China.
Ligang CuiDepartment of Ultrasound, Peking University Third Hospital, Beijing, China.
Bing CaoKey Laboratory of Cognition and Personality (SWU), Faculty of Psychology, Ministry of Education, Southwest University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundsBreast cancer is a heterogeneous disease without clear pathogenesis and effective primary prevention. The "anti-cancer" effects of several trace elements have received increasing attention in recent years. The main purpose of current study is to explore the differences of three potential "anti-cancer" trace elements selenium (Se), molybdenum (Mo), and strontium (Sr) between patients with malignant breast tumors and healthy controls.

methodsWe conducted a case-control study in 45 patients with malignant breast tumors as cases and 95 healthy volunteers as controls from Peking University Third Hospital, Beijing, China. The serum concentrations of trace elements were evaluated by using inductively coupled plasma mass spectrometry (ICP-MS).

resultsThe cases may have a lower Se levels when compared with controls (cases: 106.22 ng/ml, SD: 20.95 ng/ml; controls: 117.02 ng/ml, IQR: 22.79 ng/ml, p = 0.014). High levels of Se were a protective factor from breast cancer after adjusting the potential confounders of age, BMI, smoking, drinking, and menopause status (OR = 0.395, 95% CI, 0.178, 0.877,

conclusionsOur findings herein supported that Se has protective effects to avoid malignant breast tumors and Sr has protective effects to avoid poorly differentiated malignant breast tumors. Exploring "anti-cancer" related trace elements and their associations with breast cancer will assist for the early prevention and intervention for the disease.

Indexed as

anti-cancerICP-MSmalignantseleniumstrontium

Identifiers

PMID34447692
PMCPMC8383177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.