ArticleEvolution, medicine, and public health2021
Variants in SARS-CoV-2 associated with mild or severe outcome.
Article in Evolution, medicine, and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Association of RBD mutations with COVID-19 disease severity in the Iranian population.Virus genes · 2025Article
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- Drug Cocktail Formulation via Circuit Design.IEEE transactions on molecular, biological, and multi-scale communications · 2023Article
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- Statistical analysis supports UTR (untranslated region) deletion theory in SARS-CoV-2.Virulence · 2022Article
- Predicting COVID-19 disease severity from SARS-CoV-2 spike protein sequence by mixed effects machine learning.Computers in biology and medicine · 2022Article
- SARS-CoV-2 Amino Acid Mutations Detection in Greek Patients Infected in the First Wave of the Pandemic.Microorganisms · 2022Article
- SARS-CoV-2 and Influenza A Virus Coinfections in Ferrets.Journal of virology · 2022Article
- Mutations in the genome of severe acute respiratory syndrome coronavirus 2: implications for COVID-19 severity and progression.The Journal of international medical research · 2022Review
- Conserved Molecular Signatures in the Spike, Nucleocapsid, and Polymerase Proteins Specific for the GenusGenes · 2022Article
- Article
- Whole-genome Sequencing of SARS-CoV-2: Using Phylogeny and Structural Modeling to Contextualize Local Viral Evolution.Military medicine · 2022Article
- Impact of SARS-CoV-2 Mutations on PCR Assay Sequence Alignment.Frontiers in public health · 2022Article
- Pandemic strategies with computational and structural biology against COVID-19: A retrospective.Computational and structural biotechnology journal · 2022Review
- SARS-CoV-2 Mutations and COVID-19 Clinical Outcome: Mutation Global Frequency Dynamics and Structural Modulation Hold the Key.Frontiers in cellular and infection microbiology · 2022Article
- SARS-CoV-2 Genome-Based Severity Predictions Correspond to Lower qPCR Values and Higher Viral Load.Global health, epidemiology and genomics · 2022Article
- Severity of infection with the SARS-CoV-2 B.1.1.7 lineage among hospitalized COVID-19 patients in Belgium.PloS one · 2022Observational
- Jumping a Moving Train: SARS-CoV-2 Evolution in Real Time.Journal of the Pediatric Infectious Diseases Society · 2021Review
- Association between prognostic factors and the outcomes of patients infected with SARS-CoV-2 harboring multiple spike protein mutations.Scientific reports · 2021Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe coronavirus disease 2019 (COVID-19) pandemic is a global public health emergency causing a disparate burden of death and disability around the world. The viral genetic variants associated with outcome severity are still being discovered.
methodsWe downloaded 155 958 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from GISAID. Of these genomes, 3637 samples included useable metadata on patient outcomes. Using this subset, we evaluated whether SARS-CoV-2 viral genomic variants improved prediction of reported severity beyond age and region. First, we established whether including genomic variants as model features meaningfully increased the predictive power of our model. Next, we evaluated specific variants in order to determine the magnitude of association with severity and the frequency of these variants among SARS-CoV-2 genomes.
resultsLogistic regression models that included viral genomic variants outperformed other models (area under the curve = 0.91 as compared with 0.68 for age and gender alone;
conclusionNumerous SARS-CoV-2 variants have 2-fold or greater association with odds of mild or severe outcome and collectively, these variants are common. In addition to comprehensive mitigation efforts, public health measures should be prioritized to control the more severe manifestations of COVID-19 and the transmission chains linked to these severe cases.
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