Evidence map›Paper›PMID 34447485›Full record

ReviewOxidative medicine and cellular longevity2021

Phenolic Bioactives as Antiplatelet Aggregation Factors: The Pivotal Ingredients in Maintaining Cardiovascular Health.

Javad Sharifi-Rad, Cristina Quispe, Wissam Zam, Manoj Kumar, Susana M Cardoso, Olivia R Pereira, Adedayo O Ademiluyi, Oluwakemi Adeleke, Ana Catarina Moreira, Jelena Živković and 11 more

Open access · hybridAbstract readReview
In one paragraph

Review in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Potential Role of Polyphenols in Platelet Aggregation and Blood Coagulation.Journal of cardiovascular development and disease · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 17 institutions in 11 countries.

Javad Sharifi-RadPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID https://orcid.org/0000-0002-7301-8151
Cristina QuispeFacultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique 1110939, Chile.
Wissam ZamDepartment of Analytical and Food Chemistry, Faculty of Pharmacy, Al-Andalus University for Medical Sciences, Tartous, Syria.
Manoj KumarChemical and Biochemical Processing Division, ICAR-Central Institute for Research on Cotton Technology, Mumbai 400019, India.ORCID https://orcid.org/0000-0002-4192-6497
Susana M CardosoLAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Olivia R PereiraCentro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.
Adedayo O AdemiluyiFunctional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology, Akure, Nigeria.
Oluwakemi AdelekeFunctional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology, Akure, Nigeria.
Ana Catarina MoreiraPulmonology Department, Hospital Garcia de Orta, EPE, Almada, Lisboa, Portugal.
Jelena ŽivkovićInstitute for Medicinal Plants Research "Dr. Josif Pančić", Tadeuša Košćuška 1, 11000 Belgrade, Serbia.
Felipe NoriegaDepartment of Plant Production, Faculty of Agronomy, Universidad de Concepción, Chillan 4070386, Chile.
Seyed Abdulmajid AyatollahiPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Farzad KobarfardPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mehrdad FaiziDepartment of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Miquel MartorellDepartment of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, 4070386 Concepción, Chile.ORCID https://orcid.org/0000-0003-3183-7623
Natália Cruz-MartinsFaculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.ORCID https://orcid.org/0000-0002-5934-5201
Monica ButnariuBanat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara, Timisoara, Romania.ORCID https://orcid.org/0000-0002-2032-5000
Iulia Cristina BagiuVictor Babes University of Medicine and Pharmacy of Timisoara, Department of Microbiology, Timisoara, Romania.ORCID https://orcid.org/0000-0003-3099-8249
Radu Vasile BagiuVictor Babes University of Medicine and Pharmacy of Timisoara, Department of Microbiology, Timisoara, Romania.ORCID https://orcid.org/0000-0002-1528-5630
Mohammed M AlshehriPharmaceutical Care Department, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0002-2041-4695
William C ChoDepartment of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong.ORCID https://orcid.org/0000-0003-4174-4586
Shahid Beheshti University of Medical Sciences · IRUniversity of Concepción · CLVictor Babeș University of Medicine and Pharmacy Timișoara · ROAl Andalus University · SYArturo Prat University · CLEkiti State University · NGFederal University of Technology · NGHospital Garcia de Orta · PTICAR - Central Institute for Research on Cotton Technology · INInstitute for Plant Protection and Environment · RSNational Guard Health Affairs · SAPolytechnic Institute of Bragança · PTQueen Elizabeth Hospital · CNRede de Química e Tecnologia · PTUniversidade do Porto · PTUniversity of Karachi · PKUnivesity of Life Science "King Mihai I" from Timisoara · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular diseases (CVD) are one of the main causes of mortality in the world. The development of these diseases has a specific factor-alteration in blood platelet activation. It has been shown that phenolic compounds have antiplatelet aggregation abilities and a positive impact in the management of CVD, exerting prominent antioxidant, anti-inflammatory, antitumor, cardioprotective, antihyperglycemic, and antimicrobial effects. Thus, this review is intended to address the antiplatelet activity of phenolic compounds with special emphasis in preventing CVD, along with the mechanisms of action through which they are able to prevent and treat CVD.

Indexed as

Cardiovascular DiseasesPhenolsPhytochemicalsPlatelet Aggregation InhibitorsAnimalsHumansPlatelet AggregationPhenolsPhytochemicalsPlatelet Aggregation Inhibitors

Identifiers

PMID34447485
PMCPMC8384526
OpenAlexW3195924270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.