Evidence map›Paper›PMID 34447474›Full record

ArticleExperimental and therapeutic medicine2021

Herbal melanin induces interleukin-1β secretion and production by human THP-1 monocytes via Toll-like receptor 2 and p38 MAPK activation.

Adila El-Obeid, Wesam Bin Yahya, Bader Almuzzaini, Abeer Al Tuwaijri, Maria Najdi, Adil Hassib, Sabine Matou-Nasri

Abstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Immune Response Activation and Hepatoprotective Activity ofInternational journal of food science · 2025
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Adila El-ObeidBiobank, King Abdullah International Medical Research Center, Riyadh 11481, Saudi Arabia.
Wesam Bin YahyaCell and Gene Therapy Group, Medical Genomics Research Department, King Abdullah International Medical Research Center, Ministry of National Guard-Health Affairs, King Saud bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia.
Bader AlmuzzainiMedical Genomics Research Department, King Abdullah International Medical Research Center, Ministry of National Guard-Health Affairs; King Saud bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia.
Abeer Al TuwaijriMedical Genomics Research Department, King Abdullah International Medical Research Center, Ministry of National Guard-Health Affairs; King Saud bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia.
Maria NajdiCell and Gene Therapy Group, Medical Genomics Research Department, King Abdullah International Medical Research Center, Ministry of National Guard-Health Affairs, King Saud bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia.
Adil HassibDepartment of Physics, Faculty of Science, University of Khartoum, Khartoum 11111, Sudan.
Sabine Matou-NasriCell and Gene Therapy Group, Medical Genomics Research Department, King Abdullah International Medical Research Center, Ministry of National Guard-Health Affairs, King Saud bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herbal melanin (HM), extracted from

Indexed as

herbal melanininterleukinmonocytesTHP-1Toll-like receptor

Identifiers

PMID34447474
PMCPMC8355711

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.