Evidence map›Paper›PMID 34447426›Full record

ArticleAfrican health sciences2021

The utility of a modified WHO TB screening tool among children at a Botswana child welfare clinic.

Wame Dikobe, Mooketsi Molefi, Bornapate Nkomo, Botshelo Kgwaadira, Boingotlo Gasenelwe, Esther Seloilwe, Yohanna Mashalla, Tonya-Ascortt Mills

Abstract read
In one paragraph

Article in African health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wame DikobeMinistry of Health, Department of Public Health, TB Program, Gaborone, Botswana.
Mooketsi MolefiUniversity of Botswana, Department of Family Medicine & Public Health, Gaborone, Botswana.
Bornapate NkomoMinistry of Health, Department of Public Health, TB Program, Gaborone, Botswana.
Botshelo KgwaadiraMinistry of Health, Department of Public Health, TB Program, Gaborone, Botswana.
Boingotlo GasenelweWorld Health Organization, Country Office, Gaborone, Botswana.
Esther SeloilweUniversity of Botswana, Faculty Health Sciences, Gaborone, Botswana.
Yohanna MashallaUniversity of Botswana, Faculty Health Sciences, Gaborone, Botswana.
Tonya-Ascortt MillsBotswana-University of Pennsylvania Partnership, TB Program, Gaborone, Botswana.

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundIn high TB/HIV settings, the increased risk for TB amongst children exposed to HIV has been established through biomedical tests. Screening HIV exposed children for TB can improve early childhood TB detection and treatment.

objectiveThis study assessed the utility of a modified World Health Organization (WHO) tool by including HIV variables, to determine TB exposure amongst HIV exposed children presenting to a "Well Child" Clinic (CWC).

methodsClinical data were obtained from medical records and/or from the caregivers of children presenting to CWC. Data was analyzed to explore factors associated with positive screening for TB, including being exposed to HIV and current HIV status.

resultsFive percent (55/1100) screened reported a close TB contact and 21% (n=231) had positive TB symptom screen. History of close TB contact was a risk factor for positive screening for TB symptoms (OR 1.89 CI 1.05-3.4) while being HIV negative was protective (OR 0.3, Cl 0.19-0.62). HIV exposure was associated with increased risk of TB exposure (OR 2.9 CI 1.61-5.19).

conclusionIntegrating HIV variables in the existing WHO screening tool for childhood TB can be useful in early detection and treatment of TB in HIV exposed children in resource limited settings.

Indexed as

Ambulatory Care FacilitiesBotswanaChild, PreschoolCross-Sectional StudiesFemaleHumansInfantInfant, NewbornMaleMass ScreeningProspective StudiesTuberculosis, PulmonaryWorld Health OrganizationChildhood TB screeningHIV Exposure screeningTB/HIV integration

Identifiers

PMID34447426
PMCPMC8367304

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.