Evidence map›Paper›PMID 34447417›Full record

ArticleAfrican health sciences2021

Antiretroviral therapy outcomes among adolescents and young adults in a Tertiary hospital in Kenya.

Patrick Mburugu, Peter Muiruri, Nelly Opiyo, Justus Simba, Jane Adunda, Rosemary Kawira, Onesmus Gachuno

Abstract read
In one paragraph

Article in African health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Patrick MburuguJomo Kenyatta University of Agriculture and Technology, Child Health and Pediatrics.
Peter MuiruriKenyatta National Hospital, Kenya, Comprehensive Care Centre.
Nelly OpiyoKenyatta National Hospital, Kenya, Comprehensive Care Centre.
Justus SimbaJomo Kenyatta University of Agriculture and Technology, Child Health and Pediatrics.
Jane AdundaJomo Kenyatta University of Agriculture and Technology, Biostatistics and Actuarial Sciences.
Rosemary KawiraJomo Kenyatta University of Agriculture and Technology, School of Nursing Sciences.
Onesmus GachunoUniversity of Nairobi, Department of Obstetrics and Gynecology.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLimited data is available on the treatment outcomes of HIV infected adolescents and young adults (AYA) in sub-Saharan Africa. HIV-infected adolescents and young adults (AYA) are at high risk of developing antiretroviral treatment failure.

objectiveTo determine the clinical, immunological and virologic outcomes of AYA at a tertiary hospital in Kenya. METHODOLOGY: A longitudinal study was conducted among AYA age 10-24 years attending Kenyatta National Hospital comprehensive care center. Clinical data was abstracted from electronic medical records for study participants with at least 6 months of follow-up using a structured data abstraction sheet.

resultsA total of 250 AYA age 10 to 24 years were included. The median age was 16 years. The median CD4 cell count was 650.6 cells/mm3 (IQR 350.7-884.0). More than half (60.6%) of AYA had a CD4 cell count higher than 500 cells/mm

conclusionThe overall virologic suppression in this cohort of AYA was sub-optimal. Both immunological and virologic outcomes were worse among late adolescents (18-19 years) and young adults (20-24 years).

Indexed as

AdolescentAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountChildCross-Sectional StudiesFemaleHIV InfectionsHumansKenyaLongitudinal StudiesMaleTreatment OutcomeViral LoadYoung AdultAnti-HIV AgentsAdolescentsHIVKenyavirologic suppressionyoung adults

Identifiers

PMID34447417
PMCPMC8367303

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.