Evidence map›Paper›PMID 34447409›Full record

ArticleFrontiers in genetics2021

Genomic Copy Number Variants in CML Patients With the Philadelphia Chromosome (Ph+): An Update.

Heyang Zhang, Meng Liu, Xiaoxue Wang, Yuan Ren, Young Mi Kim, Xianfu Wang, Xianglan Lu, Hui Pang, Guangming Liu, Yue Gu and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Heyang ZhangDepartment of Hematology, The First Hospital of China Medical University, Shenyang, China.
Meng LiuDepartment of Hematology, The First Hospital of China Medical University, Shenyang, China.
Xiaoxue WangDepartment of Hematology, The First Hospital of China Medical University, Shenyang, China.
Yuan RenDepartment of Hematology, The First Hospital of China Medical University, Shenyang, China.
Young Mi KimDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Xianfu WangDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Xianglan LuDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Hui PangDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Guangming LiuDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Yue GuDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Mingran SunDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Yunpeng ShiDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Chuan ZhangDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Yaowen ZhangDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Jianqin ZhangDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Shibo LiDepartment of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Lijun ZhangDepartment of Hematology, The First Hospital of China Medical University, Shenyang, China.
University of Oklahoma Health Sciences Center · USFirst Hospital of China Medical University · CNAnshan Hospital · CNChina Medical University · CNJilin University · CNSecond Affiliated Hospital of Jilin University · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSubmicroscopic segmental imbalances detected by array-comparative genomic hybridization (array-CGH) were discovered to be common in chronic myeloid leukemia (CML) patients with

methodsKaryotyping tests were performed on 106 CML patients during January 2010-September 2019 in our Genetics Laboratory. Eighty-four (79.2%) patients had the Philadelphia (Ph) chromosome as the sole chromosomal anomaly. Only 49(58.3%) of these 84 patients had sufficient marrow or leukemia blood materials to additionally be included in the array-CGH analysis. Fluorescence

results11(22.4%) out of the 49 patients were found to have one to three somatic segmental somatic segmental (CNVs), including fourteen deletions and three duplications. The common region associated with deletions was on 9q33.3-34.12. Identified in five (45.5%) of the 11 positive patients with segmental CNVs, the deletions ranged from 106 kb to 4.1 Mb in size. Two (18.2%) cases had a deletion in the ABL1-BCR fusion gene on der (9), while three (27.3%) cases had a deletion in the ASS1 gene. The remaining CNVs were randomly distributed on different autosomes.

conclusionSubtle genomic CNVs are relatively common in CML patients without cytogenetically visible additional chromosomal aberrations (ACAs). Long-term studies investigating the potential impact on patient prognosis and treatment outcome is underway.

Indexed as

additional chromosomal aberrationsASS1 genechronic myeloid leukemiacopy number variationsdel(9q)

Identifiers

PMID34447409
PMCPMC8383316
OpenAlexW2753784732

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.