Evidence map›Paper›PMID 34447380›Full record

ArticleFrontiers in immunology2021

IgG Immune Complexes Inhibit Naïve T Cell Proliferation and Suppress Effector Function in Cytotoxic T Cells.

Wissam Charab, Matthew G Rosenberger, Haridha Shivram, Justin M Mirazee, Moses Donkor, Soumya R Shekhar, Donjeta Gjuka, Kimberly H Khoo, Jin Eyun Kim, Vishwanath R Iyer and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. The emerging role of Fusobacteria in carcinogenesis.European journal of clinical investigation · 2024
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Wissam CharabDepartment of Chemical Engineering, University of Texas at Austin, Austin, TX, United States.
Matthew G RosenbergerDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX, United States.
Haridha ShivramDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, United States.
Justin M MirazeeDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, United States.
Moses DonkorDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, United States.
Soumya R ShekharDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, United States.
Donjeta GjukaDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, United States.
Kimberly H KhooDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, United States.
Jin Eyun KimDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX, United States.
Vishwanath R IyerDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, United States.
George GeorgiouDepartment of Chemical Engineering, University of Texas at Austin, Austin, TX, United States.
The University of Texas at Austin · US

Funding

Systematic, molecular level analysis of the Fc receptor ligation on antibody effector functionsU01AI148118 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI GEORGIOU, GEORGE GEORGIOU, VARADARAJAN, NAVIN · 2020 to 2024
$2.3M
NIAID NIH HHS U01 AI148118
6 · The paper itself

Abstract

Elevated levels of circulating immune complexes are associated with autoimmunity and with worse prognoses in cancer. Here, we examined the effects of well-defined, soluble immune complexes (ICs) on human peripheral T cells. We demonstrate that IgG-ICs inhibit the proliferation and differentiation of a subset of naïve T cells but stimulate the division of another naïve-like T cell subset. Phenotypic analysis by multi-parameter flow cytometry and RNA-Seq were used to characterize the inhibited and stimulated T cells revealing that the inhibited subset presented immature features resembling those of recent thymic emigrants and non-activated naïve T cells, whereas the stimulated subset exhibited transcriptional features indicative of a more differentiated, early memory progenitor with a naïve-like phenotype. Furthermore, we show that while IgG1-ICs do not profoundly inhibit the proliferation of memory T cells, IgG1-ICs suppress the production of granzyme-β and perforin in cytotoxic memory T cells. Our findings reveal how ICs can link humoral immunity and T cell function.

Indexed as

ImmunomodulationAnimalsAntigen-Antibody ComplexAntigen PresentationAutoimmunityBiomarkersCell CommunicationGene Expression ProfilingHumansImmunoglobulin GImmunophenotypingLymphocyte ActivationMemory T CellsMiceT-Lymphocytes, CytotoxicT-Lymphocyte SubsetsAntigen-Antibody ComplexBiomarkersImmunoglobulin GAntigen and Antibody Immune ComplexesIgG Immune Complexes (ICs)Naive and memory T cellsT cell activation proliferation and inhibitionT cell antibody receptorsT cell Fc Gamma Receptors (FcgR)T cell Fc ReceptorsT cell non-canonical Fc Receptors

Identifiers

PMID34447380
PMCPMC8383740
OpenAlexW3192396465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.