Evidence map›Paper›PMID 34447366›Full record

ArticleFrontiers in immunology2021

Oral Fc-Coupled Preproinsulin Achieves Systemic and Thymic Delivery Through the Neonatal Fc Receptor and Partially Delays Autoimmune Diabetes.

Noémie Corcos, Slobodan Culina, Claire Deligne, Cassandra Lavaud, Sylvaine You, Roberto Mallone

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Noémie CorcosUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, France.
Slobodan CulinaUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, France.
Claire DeligneUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, France.
Cassandra LavaudUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, France.
Sylvaine YouUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, France.
Roberto MalloneUniversité de Paris, Institut Cochin, CNRS, INSERM, Paris, France.
Institut Cochin · FRUniversité Paris Cité · FRCentre National de la Recherche Scientifique · FR

Funding

CIHR
6 · The paper itself

Abstract

Tolerogenic vaccinations using beta-cell antigens are attractive for type 1 diabetes prevention, but clinical trials have been disappointing. This is probably due to the late timing of intervention, when multiple auto-antibodies are already present. We therefore devised a strategy to introduce the initiating antigen preproinsulin (PPI) during neonatal life, when autoimmunity is still silent and central tolerance mechanisms, which remain therapeutically unexploited, are more active. This strategy employs an oral administration of PPI-Fc, i.e. PPI fused with an IgG Fc to bind the intestinal neonatal Fc receptor (FcRn) that physiologically delivers maternal antibodies to the offspring during breastfeeding. Neonatal oral PPI-Fc vaccination did not prevent diabetes development in PPI T-cell receptor-transgenic G9C8.NOD mice. However, PPI-Fc was efficiently transferred through the intestinal epithelium in an Fc- and FcRn-dependent manner, was taken up by antigen presenting cells, and reached the spleen and thymus. Although not statistically significant, neonatal oral PPI-Fc vaccination delayed diabetes onset in polyclonal

Indexed as

Administration, OralAnimalsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Histocompatibility Antigens Class IInsulinMiceMice, Inbred NODMice, KnockoutProtein PrecursorsReceptors, FcRecombinant Fusion ProteinsThymus GlandFc receptor, neonatalHistocompatibility Antigens Class IInsulinpreproinsulinProtein PrecursorsReceptors, FcRecombinant Fusion Proteinsautoimmunityimmune toleranceneonatal Fc receptor (FcRn)preproinsulinT cellsthymustype 1 diabetesvaccination

Identifiers

PMID34447366
PMCPMC8382691
OpenAlexW3192453605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.