Evidence map›Paper›PMID 34447297›Full record

ArticleFrontiers in cellular neuroscience2021

Dysregulated Microglial Cell Activation and Proliferation Following Repeated Antigen Stimulation.

Sujata Prasad, Wen S Sheng, Shuxian Hu, Priyanka Chauhan, James R Lokensgard

Abstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sujata PrasadNeurovirology Laboratory, Department of Medicine, University of Minnesota, Minneapolis, MN, United States.
Wen S ShengNeurovirology Laboratory, Department of Medicine, University of Minnesota, Minneapolis, MN, United States.
Shuxian HuNeurovirology Laboratory, Department of Medicine, University of Minnesota, Minneapolis, MN, United States.
Priyanka ChauhanNeurovirology Laboratory, Department of Medicine, University of Minnesota, Minneapolis, MN, United States.
James R LokensgardNeurovirology Laboratory, Department of Medicine, University of Minnesota, Minneapolis, MN, United States.

Funding

Role of B-cells and CNS antibodies in modulating chronic microglial activationR01NS038836 · NINDS · UNIVERSITY OF MINNESOTA · PI LOKENSGARD, JAMES R · 2000 to 2022
$7.3M
T lymphocyte-induced glial activation during CNS immune reconstitution diseaseR01MH066703 · NIMH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LOKENSGARD, JAMES R · 2003 to 2023
$6.9M
NIMH NIH HHS R01 MH066703NINDS NIH HHS R01 NS038836
6 · The paper itself

Abstract

Upon reactivation of quiescent neurotropic viruses antigen (Ag)-specific brain resident-memory CD8+ T-cells (bT

Indexed as

immune activationmicroglianeurotoxicityreactive gliosisresident memory T-cellsviral reactivation

Identifiers

PMID34447297
PMCPMC8383069

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.