Evidence map›Paper›PMID 34447269›Full record

ArticleCancer management and research2021

Diagnostic Value of Serum lncRNA HOTAIR Combined with Galectin-3 in Benign and Papillary Thyroid Carcinoma.

Li Li, Jianjun Wang, Zhongquan Li, Shuang Qiu, Junyu Cao, Yuan Zhao, Zhenfan Huang, Jie He, Feipeng Luo, Kunxian Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer management and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  8. Nrf2 as a novel diagnostic biomarker for papillary thyroid carcinoma.European journal of histochemistry : EJH · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Li Li *Department of Breast and Thyroid Surgery, The First People's Hospital of Yunnan Province (Kunhua Hospital Affiliated to Kunming University of Science and Technology), Kunming, Yunnan, 650032, People's Republic of China.
Jianjun Wang *Department of Breast and Thyroid Surgery, The First People's Hospital of Yunnan Province (Kunhua Hospital Affiliated to Kunming University of Science and Technology), Kunming, Yunnan, 650032, People's Republic of China.
Zhongquan LiDepartment of Anesthesiology, Yunnan General Hospital of Armed Police, Kunming, Yunnan, 650032, People's Republic of China.
Shuang QiuDepartment of Breast and Thyroid Surgery, The First People's Hospital of Yunnan Province (Kunhua Hospital Affiliated to Kunming University of Science and Technology), Kunming, Yunnan, 650032, People's Republic of China.
Junyu CaoDepartment of Breast and Thyroid Surgery, The First People's Hospital of Yunnan Province (Kunhua Hospital Affiliated to Kunming University of Science and Technology), Kunming, Yunnan, 650032, People's Republic of China.
Yuan ZhaoDepartment of Breast and Thyroid Surgery, The First People's Hospital of Yunnan Province (Kunhua Hospital Affiliated to Kunming University of Science and Technology), Kunming, Yunnan, 650032, People's Republic of China.
Zhenfan HuangDepartment of Breast and Thyroid Surgery, The First People's Hospital of Yunnan Province (Kunhua Hospital Affiliated to Kunming University of Science and Technology), Kunming, Yunnan, 650032, People's Republic of China.
Jie HeDepartment of Breast and Thyroid Surgery, The First People's Hospital of Yunnan Province (Kunhua Hospital Affiliated to Kunming University of Science and Technology), Kunming, Yunnan, 650032, People's Republic of China.
Feipeng LuoDepartment of Cardiothoracic Surgery, The Second People's Hospital of Baoshan City, Kunming, Yunnan, 650032, People's Republic of China.
Kunxian YangDepartment of Breast and Thyroid Surgery, The First People's Hospital of Yunnan Province (Kunhua Hospital Affiliated to Kunming University of Science and Technology), Kunming, Yunnan, 650032, People's Republic of China.
First People's Hospital of Yunnan Province · CNKunming University of Science and Technology · CNSecond People's Hospital of Yunnan Province · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePapillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. LncRNA HOTAIR (HOx Transcript AntIsense RNA) and Galectin-3 are involved in PTC. This study explored the clinical effect of lncRNA HOTAIR/Galectin-3 on PTC patients.

methodsSubjects were assigned into PTC (160 cases) and benign thyroid tumor groups (150 cases). Fasting peripheral venous blood was collected. LncRNA HOTAIR/Galectin-3 expressions in serum were detected. Subjects were assigned into HOTAIR/Glactin-3 high/low expression groups and their correlation with age, gender, BMI, tumor size, pathological stage, TSH, TPO-Ab, and TG-Ab in PTC was analyzed. Receiver operating characteristic (ROC) curve was conducted on diagnostic efficacy of HOTAIR or/and Galectin-3. The difference of area under the curve (AUC) was compared and analyzed.

resultsHOTAIR and Glactin-3 were higher in PTC group and correlated with tumor pathological stage. Higher HOTAIR/Glactin-3 expression indicated a more advanced TNM stage. LncRNA HOTAIR was positively correlated with TPO-Ab and TG-Ab. AUC of HOTAIR for PTC diagnosis was 0.895, with 96.00% specificity and 80.63% sensitivity. AUC of Glactin-3 for PTC diagnosis was 0.817, with 66.67% specificity and 78.75% sensitivity. AUC of HOTAIR combining with Glactin-3 for PTC diagnosis was 0.969 with 96.00% specificity and 87.50% sensitivity. AUC of lncRNA HOTAIR was higher than that of Glactin-3, while AUC of the combination was higher than that of lncRNA HOTAIR or Glactin-3.

conclusionLncRNA HOTAIR and Glactin-3 were highly expressed in PTC. The combination detection of lncRNA HOTAIR/Glactin-3 had higher diagnostic efficiency on the differential diagnosis of benign thyroid tumor and PTC.

Indexed as

benign thyroid tumorcombination detectiondiagnostic efficiencyGlactin-3LncRNA HOTAIRpapillary thyroid carcinomaPTCROC curve analysisTPO-Ab

Identifiers

PMID34447269
PMCPMC8382966
OpenAlexW3195592136

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.