Evidence map›Paper›PMID 34447254›Full record

ArticleAdvances and applications in bioinformatics and chemistry : AABC2021

Antimicrobial Activity, in silico Molecular Docking, ADMET and DFT Analysis of Secondary Metabolites from Roots of Three Ethiopian Medicinal Plants.

Mathewos Anza, Milkyas Endale, Luz Cardona, Diego Cortes, Rajalakshmanan Eswaramoorthy, Jesus Zueco, Hortensia Rico, Maria Trelis, Belen Abarca

Open access · goldAbstract read
In one paragraph

Article in Advances and applications in bioinformatics and chemistry : AABC, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 68 citations in OpenAlex.

  1. Chemical Profiling and Antimicrobial Activity of the Leaf Essential Oil ofInternational journal of molecular sciences · 2026
    Article
  2. Article
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  4. Natural Protective Mechanisms ofPathogens (Basel, Switzerland) · 2026
    Article
  5. [Fe(phen)ACS omega · 2025
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  12. Eco-Friendly SpeciesACS omega · 2024
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  13. Article
  14. Article
  15. Article
  16. Article
  17. Metabolites · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Mathewos AnzaDepartment of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, Adama, Ethiopia.
Milkyas EndaleDepartment of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, Adama, Ethiopia.
Luz CardonaDepartment of Organic Chemistry, Faculty of Chemistry, University of Valencia, Burjassot, Spain.
Diego CortesDepartment of Pharmacology, Faculty of Pharmacy, University of Valencia, Burjassot, Spain.
Rajalakshmanan EswaramoorthyDepartment of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, Adama, Ethiopia.ORCID 0000-0002-8331-2100
Jesus ZuecoDepartment of Microbiology and Ecology, Faculty of Pharmacy, University of Valencia, Burjassot, Spain.
Hortensia RicoDepartment of Microbiology and Ecology, Faculty of Pharmacy, University of Valencia, Burjassot, Spain.
Maria TrelisParasites and Health Research Group, Department of Pharmacy, Pharmaceutical Technology and Parasitology, Faculty of Pharmacy, University of Valencia, Burjassot, Spain.
Belen AbarcaDepartment of Organic Chemistry, Faculty of Chemistry, University of Valencia, Burjassot, Spain.
Universitat de València · ESAdama Science and Technology University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

methodsSilica gel column chromatographic separation was used to isolate compounds. Crude extract and isolated compounds were evaluated for antimicrobial activity against

resultsSilica gel column chromatographic separation afforded five compounds

conclusionThe results obtained suggest that N-methyl-2,3-bis(2-hydroxybenzyl)-1Н-indol (

Indexed as

ADMETantimicrobialClematis burgensisDFT analysisEuphorbia schimperianamolecular dockingUvaria scheffleri

Identifiers

PMID34447254
PMCPMC8384431
OpenAlexW3195295849

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.