ArticleJournal of pharmacy & bioallied sciences2021
Assessment of Age-Related Changes of Salivary Immunoglobulin A Levels among Healthy Individuals.
Article in Journal of pharmacy & bioallied sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Salivary cortisol: Biomarker for stress during routine dental extractions - A prospective comparative study.Bioinformation · 2026Article
- Article
- The Effect of Biological Treatment on Stress Parameters Determined in Saliva in Patients with Severe Psoriasis.Medicina (Kaunas, Lithuania) · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSecretory immunoglobulin A (IgA) is the first line of defense against pathogens that invade mucosal surfaces. It has been reported that the immune system exhibits profound age-related changes. The aim of this study was to investigate the age-dependent changes of salivary IgA among healthy individuals. MATERIALS AND
methodsSaliva samples were collected from 120 healthy individuals (aged 11-70 years). The salivary IgA concentrations were measured by the use of a single radial immunodiffusion technique and analyzed using the Mann-Whitney U, Kruskal-Wallis, and Chi-square tests.
resultsThe mean salivary IgA levels were 81.11 ± 4.50 mg/dl at age 11-20 years, 92.71 ± 13.76 mg/dl at age 21-30 years, 96.50 ± 4.04 mg/dl at age 31-40 years, 104.96 ± 10.15 mg/dl at age 41-50 years, 113.22 ± 7.85 mg/dl at age 51-60 years, and 91.38 ± 4.77 mg/dl at age 61-70 years. There was a significant difference among the mean salivary IgA levels of different age groups (
conclusionThese results showed that the salivary IgA levels exhibit age-related changes. Oral immunization may be considered to improve oral immunity when the salivary concentrations of IgA begin to decrease during lifetime.
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