ArticleJournal of pharmacy & bioallied sciences2021
Clinico-microbiological Efficacy of Indocyanine Green as a Novel Photosensitizer for Photodynamic Therapy among Patients with Chronic Periodontitis: A Split-mouth Randomized Controlled Clinical Trial.
Article in Journal of pharmacy & bioallied sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri-implant diseases.The Cochrane database of systematic reviews · 2024Pooled it
- Indocyanine Green as a Photosensitizer in Periodontitis Treatment: A Systematic Review of Randomized Controlled Trials.Life (Basel, Switzerland) · 2025Review
- Effectiveness of photodynamic therapy on the treatment of chronic periodontitis: a systematic review during 2008-2023.Frontiers in chemistry · 2024Review
- Indocyanine green mediated antimicrobial photodynamic therapy: A non-invasive treatment approach for chronic periodontitis with type 2 diabetes mellitus: A randomized controlled clinical trial.Journal of oral biology and craniofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveConventional nonsurgical periodontal therapy, i.e., scaling and root planing (SRP), is not sufficient to completely eradicate the microorganisms present in dental plaque biofilm due to the incapability of instruments to reach the inaccessible areas of a tooth with anatomical variations. Hence, to increase the effectiveness of SRP, many adjunctive treatment strategies are proposed, including photodynamic therapy (PDT). Therefore, the purpose of this study was to determine the clinical and microbiological efficacy of PDT using Indocyanine green (ICG) as a novel photosensitizer for the treatment of chronic periodontitis. MATERIALS AND
methodsTwenty individuals who fulfilled the eligibility criteria were enrolled for this randomized controlled clinical trial using split-mouth design. Treatment sites from each individual were randomly allocated into two groups: SRP was done for the sites of the control group and an additional session of PDT using ICG was performed for the sites of the test group. Subgingival plaque samples were collected from both the sites and sent for quantitative analysis of
resultsAfter 3 months, PD and CAL showed statistically significant improvement in the test sites (
conclusionICG as a photosensitizer may enhance the outcomes of SRP and can be used for PDT for the nonsurgical management of periodontal diseases.
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Registered trials
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