Evidence map›Paper›PMID 34447008›Full record

ArticleAnnals of Indian Academy of Neurology

Sunita Bijarnia-Mahay, Gaurav Roy, Quasar S Padiath, Renu Saxena, Ishwar Chander Verma

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of Indian Academy of Neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Sunita Bijarnia-MahayInstitute of Medical Genetics and Genomics, Sir Ganga Ram Hospital, New Delhi, India.
Gaurav RoyInstitute of Medical Genetics and Genomics, Sir Ganga Ram Hospital, New Delhi, India.
Quasar S PadiathDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburg, Pittsburgh, PA, USA.
Renu SaxenaInstitute of Medical Genetics and Genomics, Sir Ganga Ram Hospital, New Delhi, India.
Ishwar Chander VermaInstitute of Medical Genetics and Genomics, Sir Ganga Ram Hospital, New Delhi, India.
Sir Ganga Ram Hospital · INPittsburg State University · US

Funding

Elucidating mechanisms involved in Lamin B1 mediated demyelinationR01NS095884 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PADIATH, QUASAR S · 2016 to 2020
$2.1M
High-content screening for modulators of lamin B1 as a therapeutic target in autosomal dominant leukodystrophyR33NS106087 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PADIATH, QUASAR S, VOGT, ANDREAS · 2019 to 2020
$783k
Exploring Antisense Oligonucleotides as a potential therapy for Autosomal Dominant LeukodystrophyR33NS104384 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PADIATH, QUASAR S · 2020 to 2021
$748k
Studying the role of the nuclear lamina in age dependent demyelinationR21AG046897 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PADIATH, QUASAR S · 2013 to 2014
$434k
High-content screening for modulators of lamin B1 as a therapeutic target in autosomal dominant leukodystrophyR21NS106087 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PADIATH, QUASAR S, VOGT, ANDREAS · 2018 to 2018
$391k
Exploring Antisense Oligonucleotides as a potential therapy for Autosomal Dominant LeukodystrophyR21NS104384 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PADIATH, QUASAR S · 2018 to 2018
$353k
NIA NIH HHS R21 AG046897NINDS NIH HHS R01 NS095884NINDS NIH HHS R21 NS104384NINDS NIH HHS R21 NS106087NINDS NIH HHS R33 NS104384NINDS NIH HHS R33 NS106087
6 · The paper itself

Abstract

Autosomal dominant leukodystrophy is an adult onset neurodegenerative disorder presenting with progressive symptoms of ataxia and autonomic dysfunction in fourth or fifth decade in life. It has clinical similarity with multiple sclerosis, but shows characteristic magnetic resonance imaging findings of diffuse bilaterally symmetrical leukodystrophy which can distinguish this disorder. It is a rare disorder with no known treatment till date, and has never been described from the Indian subcontinent. We present an Indian family with autosomal dominant adult-onset demyelinating leukodystrophy with multiple members affected over four generations, and demonstrate a cheap and accurate molecular method of real-time polymerase chain reaction to detect the

Indexed as

ADLDadult-onset leukodystrophyautonomic dysfunctionlamin BLMNB1

Identifiers

PMID34447008
PMCPMC8370147
OpenAlexW3165338691

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.