Evidence map›Paper›PMID 34446979›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering2020

Developing a novel hyperspectral imaging cryomacrotome for whole body fluorescence imaging.

Boyu Meng, Brook K Byrd, Dennis J Wirth, Rendall R Strawbridge, Scott C Davis

Abstract read
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Boyu MengThayer School of Engineering, Dartmouth College, Hanover, NH 03755.
Brook K ByrdThayer School of Engineering, Dartmouth College, Hanover, NH 03755.
Dennis J WirthThayer School of Engineering, Dartmouth College, Hanover, NH 03755.
Rendall R StrawbridgeThayer School of Engineering, Dartmouth College, Hanover, NH 03755.
Scott C DavisThayer School of Engineering, Dartmouth College, Hanover, NH 03755.

Funding

Multi-probe fluorescence imaging for rapid intra-operative tumor margin assessmentR01CA188491 · NCI · DARTMOUTH COLLEGE · PI DAVIS, SCOTT C · 2015 to 2019
$2.9M
MRI fluorescence tomography for quantifying tumor receptor concentration in vivoR01CA184354 · NCI · DARTMOUTH COLLEGE · PI DAVIS, SCOTT C · 2014 to 2018
$2.6M
NCI NIH HHS R01 CA184354NCI NIH HHS R01 CA188491
6 · The paper itself

Abstract

The ability to directly measure whole-body fluorescence can enable tracking of labeled cells, metastatic spread, and drug bio-distribution. We describe the development of a new hyperspectral imaging whole body cryo-macrotome designed to acquire 3-D fluorescence volumes in large specimens (whole animals) at high resolution. The use of hyperspectral acquisition provides full spectra at every voxel, enabling spectral decoupling of multiple fluorohpores and autofluorescence. We present examples of tissue spectra and spectral fitting in a rodent glioma xenograft.

Indexed as

drug bio-distributionfluorescence molecular imaginghyperspectralmacrotomevolumetric imaging

Identifiers

PMID34446979
PMCPMC8386500

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.