ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2022
Prefrontal-hippocampal interactions supporting the extinction of emotional memories: the retrieval stopping model.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 95 citations in OpenAlex.
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- Emotion regulation modulates subsequent control of unwanted memories.Social cognitive and affective neuroscience · 2026Article
- Filtering the noise: a cerebellar-centered framework for understanding and treating mental illness -a paradigm shift in psychiatry.Frontiers in psychiatry · 2026Article
- β-catenin deficiency in forebrain excitatory neurons induces fear memory deficits and physiological alterations.Brain communications · 2026Article
- Adverse Childhood Experiences Underlie Race-Related Differences in Neural Reactivity to Stress.Behavioural neurology · 2026Article
- Dissociable memory modulation mechanisms facilitate fear amnesia at different timescales.eLife · 2025Article
- Hippocampal ensembles regulate circuit-induced relapse of extinguished fear.Molecular psychiatry · 2025Article
- Hippocampal pyramidal cells of the CA1 region are not a major target of the thalamic nucleus reuniens.PLoS biology · 2025Article
- Perinatal Exposure to Metal Mixtures Disrupts Neuronal Function and Behavior.bioRxiv : the preprint server for biology · 2025Article
- Prefrontal-hippocampal pathways underlying adolescent resilience.European child & adolescent psychiatry · 2025Article
- Dysfunction in primate dorsolateral prefrontal area 46 affects motivation and anxiety.Science (New York, N.Y.) · 2025Article
- Brief Manual for Multi-Modal Motion-Assisted Memory Desensitization and Reconsolidation Therapy for the Treatment of Post-traumatic Stress Disorder.Psychiatry and clinical psychopharmacology · 2025Article
- Evolving Psychotherapeutic Approaches for PTSD: Beyond the Fear-Based Model.Psychiatry and clinical psychopharmacology · 2025Article
- Brain mechanisms underlying the inhibitory control of thought.Nature reviews. Neuroscience · 2025Review
- Dissociative experiences alter resting state functional connectivity after childhood abuse.Scientific reports · 2025Article
- Meta analysis of resting frontal alpha asymmetry as a biomarker of depression.Npj mental health research · 2025Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Neuroimaging has revealed robust interactions between the prefrontal cortex and the hippocampus when people stop memory retrieval. Efforts to stop retrieval can arise when people encounter reminders to unpleasant thoughts they prefer not to think about. Retrieval stopping suppresses hippocampal and amygdala activity, especially when cues elicit aversive memory intrusions, via a broad inhibitory control capacity enabling prepotent response suppression. Repeated retrieval stopping reduces intrusions of unpleasant memories and diminishes their affective tone, outcomes resembling those achieved by the extinction of conditioned emotional responses. Despite this resemblance, the role of inhibitory fronto-hippocampal interactions and retrieval stopping broadly in extinction has received little attention. Here we integrate human and animal research on extinction and retrieval stopping. We argue that reconceptualising extinction to integrate mnemonic inhibitory control with learning would yield a greater understanding of extinction's relevance to mental health. We hypothesize that fear extinction spontaneously engages retrieval stopping across species, and that controlled suppression of hippocampal and amygdala activity by the prefrontal cortex reduces fearful thoughts. Moreover, we argue that retrieval stopping recruits extinction circuitry to achieve affect regulation, linking extinction to how humans cope with intrusive thoughts. We discuss novel hypotheses derived from this theoretical synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.