Observational studyScientific reports2021
Changes in copeptin levels before and 3 months after transsphenoidal surgery according to the presence of postoperative central diabetes insipidus.
Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- COPeptin Evaluation in argininevasopressin Deficiency post transsphenoidal surgery (COPED study).Pituitary · 2026Article
- Automated segmentation of pituitary adenomas, pituitary gland, and internal carotid arteries on routine coronal contrast-enhanced T1-weighted MRI: a single-sequence feasibility study.Frontiers in endocrinology · 2026Article
- Preoperative Serum Copeptin Can Predict Delayed Hyponatremia after Pituitary Surgery in the Absence of Arginine Vasopressin Deficiency.Endocrinology and metabolism (Seoul, Korea) · 2024Observational
- Use of copeptin in interpretation of the water deprivation test.Endocrinology, diabetes & metabolism · 2023Article
- Copeptin analysis in endocrine disorders.Frontiers in endocrinology · 2023Review
- Diagnosis and Management of Central Diabetes Insipidus in Adults.The Journal of clinical endocrinology and metabolism · 2022Review
- Integrating network pharmacology and experimental verification to explore the mechanism of puerarin against oliguria in acute alcoholism.Frontiers in pharmacology · 2022Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Copeptin levels reflect arginine vasopressin (AVP) release from the hypothalamus. Pituitary surgery often impairs AVP release and results in central diabetes insipidus (CDI). Here, we aimed to investigate how serum copeptin level changes 3 months after pituitary surgery and whether it has a diagnostic value for postoperative permanent CDI. Consecutive patients who underwent endoscopic transsphenoidal surgery at a single tertiary hospital were recruited. Serum copeptin levels were measured preoperatively and 3 months postoperatively. Among 88 patients, transient and permanent CDI occurred in 17 (19.3%) and 23 (26.1%), respectively. Three-month postoperative copeptin levels significantly declined from preoperative levels in permanent CDI group (P < 0.001, percentage difference = - 42.2%) and also in the transient CDI group (P = 0.002, - 27.2%). Three months postoperative copeptin level < 1.9 pmol/L under normal serum sodium levels was the optimal cutoff value for diagnosing permanent CDI with an accuracy of 81.8%, while 3-month postoperative copeptin level ≥ 3.5 pmol/L excluded the CDI with a negative predictive value of 100%. Conclusively, 3 months postoperative copeptin levels significantly decreased from preoperative levels in the transient CDI group as well as the permanent CDI group. Three-month postoperative copeptin levels ≥ 3.5 pmol/L under normal serum sodium levels may be diagnostic for excluding postoperative CDI.
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