ArticleScientific reports2021
Optical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Retinal Ganglion Cell Function and Perfusion following Intraocular Pressure Reduction with Preservative-Free Latanoprost in Patients with Glaucoma and Ocular Hypertension.Journal of clinical medicine · 2024Article
- Longitudinal Observation of Retinal Response to Optic Nerve Transection in Rats Using Visible Light Optical Coherence Tomography.Investigative ophthalmology & visual science · 2023Article
- Evaluation of macular microvascular density using optical coherence tomography angiography in patients with Posner-Schlossman syndrome.BMC ophthalmology · 2022Observational
- Analysis of Microcirculation Changes in the Macular Area and Para-Optic Disk Region After Implantable Collamer Lens Implantation in Patients With High Myopia.Frontiers in neuroscience · 2022Article
- Multipressure Dial Goggle Effects on Circumpapillary Structure and Microvasculature in Glaucoma Patients.Ophthalmology. GlaucomaArticle
- Widefield OCT Angiography and Euclidian Distance Analysis of Microvascular Deficits in Glaucomatous Eyes.Ophthalmology. GlaucomaArticle
- Pulsatile Ocular Blood Flow Registered with Optical Coherence Tomography Angiography in Patients with High Intraocular Pressure.Journal of current ophthalmologyArticle
- Quantification of vascular morphology in optical coherence tomography angiography in primary open angle glaucoma.Advances in ophthalmology practice and researchArticle
- The impact of intraocular pressure on optical coherence tomography angiography: A review of current evidence.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyReview
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
We investigated the time and location of retinal perfusion recovery after surgical intraocular pressure (IOP) lowering in glaucoma by using optical coherent tomography angiography (OCTA). Seventeen patients were analyzed. The 4.5 × 4.5-mm OCTA scans centered on the disc were performed preoperatively and postoperatively at 6 weeks, 3 months, and 6 months. The peripapillary retinal nerve fiber layer (NFL) thickness, NFL plexus capillary density (NFLP-CD) and visual field (VF) were measured overall and in 8 corresponding sectors. The low-perfusion area (LPA) was used to assess the cumulative area where local NFLP-CD was significantly below normal. At 6 months, the average IOP decreased 5.3 mmHg (P = 0.004), LPA decreased by 15% (P = 0.005), and NFLP-CD improved by 12% (P < 0.001). The NFL thickness and VF mean deviation didn't change significantly at any time point. Among the sectors with significant preoperative NFLP-CD loss, the recovery at 6 months was greatest in sectors with minimal preoperative NFL thinning (P < 0.001). In conclusion, surgical IOP lowering may improve NFLP capillary perfusion after 6 months. The perfusion recovery tended to occur in areas with minimal NFL thinning at baseline. OCTA parameters may have potential usefulness as pharmacodynamic biomarkers for glaucoma therapy.
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Registered trials
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