ArticleScientific reports2021
Multicolor imaging of calcium-binding proteins in human kidney stones for elucidating the effects of proteins on crystal growth.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- A holistic guide to effective prevention and treatment for kidney stones: a systematic review exploring anti-urolithiasis approaches.Naunyn-Schmiedeberg's archives of pharmacology · 2026Pooled it
- Cooling-induced brushite crystallization in urine as a predictive risk marker for calcium kidney stone recurrence.Urolithiasis · 2025Article
- Advances in the mechanism of urinary proteins in calcium oxalate kidney stone formation.Urolithiasis · 2025Review
- Kidney Stones as Minerals: How Methods from Geology Could Inform Urolithiasis Treatment.Journal of clinical medicine · 2025Review
- Characteristics of kidney stone-modulatory proteins decoded from proteins identified in stone matrix and urine of stone formers and non-stone subjects.Computational and structural biotechnology journal · 2025Article
- Multi - dimensional mechanism analysis ofFrontiers in pharmacology · 2025Article
- Identifying therapeutic targets for kidney stone disease through proteome-wide Mendelian randomization and colocalization analysis.Urolithiasis · 2024Article
- Impact of diet on renal stone formation.Journal of family medicine and primary care · 2024Review
- Oscillatory zoning of minerals as a fingerprint of impurity-mediated growth.Scientific reports · 2024Article
- The impact of crystal phase transition on the hardness and structure of kidney stones.Urolithiasis · 2024Article
- Article
- Roles of heat-shock protein 90 and its four domains (N, LR, M and C) in calcium oxalate stone-forming processes.Cellular and molecular life sciences : CMLS · 2022Article
- BMI mediates the association between red cell distribution width to serum albumin index and kidney stone risk: a population-based study.Therapeutic advances in urologyArticle
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Authors and funding
17 authors at 6 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The pathogenesis of kidney stone formation includes multi-step processes involving complex interactions between mineral components and protein matrix. Calcium-binding proteins in kidney stones have great influences on the stone formation. The spatial distributions of these proteins in kidney stones are essential for evaluating the in vivo effects of proteins on the stone formation, although the actual distribution of these proteins is still unclear. We reveal micro-scale distributions of three different proteins, namely osteopontin (OPN), renal prothrombin fragment 1 (RPTF-1), and calgranulin A (Cal-A), in human kidney stones retaining original mineral phases and textures: calcium oxalate monohydrate (COM) and calcium oxalate dihydrate (COD). OPN and RPTF-1 were distributed inside of both COM and COD crystals, whereas Cal-A was distributed outside of crystals. OPN and RPTF-1 showed homogeneous distributions in COM crystals with mosaic texture, and periodically distributions parallel to specific crystal faces in COD crystals. The unique distributions of these proteins enable us to interpret the different in vivo effects of each protein on CaOx crystal growth based on their physico-chemical properties and the complex physical environment changes of each protein. This method will further allow us to elucidate in vivo effects of different proteins on kidney stone formation.
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