ArticleNature communications2021
Global phylogenomic analyses of Mycobacterium abscessus provide context for non cystic fibrosis infections and the evolution of antibiotic resistance.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- Subspecies Identification and Characterization of Drug Resistance and Virulence Factors in Clinical Strains ofInfectious disease reports · 2026Article
- Genetic analysis ofiScience · 2026Article
- Modifications to a vegan artificial honey result in inhibitory activity against Mycobacterium abscessus.PloS one · 2026Article
- Clinical emergence of inducible macrolide resistance mediated by acquiredAntimicrobial agents and chemotherapy · 2025Article
- Circling in on plasmids: benchmarking plasmid detection and reconstruction tools for short-read data from diverse species.Briefings in bioinformatics · 2025Article
- Whole-genome recombination and dynamic accessory genomes drive the phenotypic diversity of Mycobacterium abscessus subspecies.Annals of clinical microbiology and antimicrobials · 2025Article
- Subspecies distribution and drug-resistance characteristics ofMicrobiology spectrum · 2025Article
- Infection by Clonally RelatedAmerican journal of respiratory and critical care medicine · 2025Article
- Macrolide resistance inJAC-antimicrobial resistance · 2025Review
- Genomic Epidemiology of Mycobacterium abscessus on the Island of Montréal Is Not Suggestive of Health Care-Associated Person-to-Person Transmission.The Journal of infectious diseases · 2025Article
- Polymicrobial infection in cystic fibrosis and future perspectives for improving Mycobacterium abscessus drug discovery.npj antimicrobials and resistance · 2024Review
- Distinct Escherichia coli transcriptional profiles in the guts of recurrent UTI sufferers revealed by pangenome hybrid selection.Nature communications · 2024Article
- Preclinical murine models for the testing of antimicrobials against Mycobacterium abscessus pulmonary infections: Current practices and recommendations.Tuberculosis (Edinburgh, Scotland) · 2024Review
- DistinctbioRxiv : the preprint server for biology · 2024Article
- Microevolution, reinfection and highly complex genomic diversity in patients with sequential isolates of Mycobacterium abscessus.Nature communications · 2024Article
- Notes from the Field: Nontuberculous Mycobacteria Infections After Cosmetic Surgery Procedures in Florida - Nine States, 2022-2023.MMWR. Morbidity and mortality weekly report · 2024Article
- Clinically relevant mutations in the PhoR sensor kinase of host-adaptedMicrobiology spectrum · 2023Article
- Genome-Scale Characterization ofInternational journal of molecular sciences · 2023Article
- The problem of Mycobacterium abscessus complex: multi-drug resistance, bacteriophage susceptibility and potential healthcare transmission.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Mycobacterium abscessus (MAB) is an emerging pathogen that leads to chronic lung infections. To date, the global population structure of non-cystic fibrosis (CF) MAB and evolutionary patterns of drug resistance emergence have not been investigated. Here we construct a global dataset of 1,279 MAB whole genomes from CF or non-CF patients. We utilize whole genome analysis to assess relatedness, phylogeography, and drug resistance evolution. MAB isolates from CF and non-CF hosts are interspersed throughout the phylogeny, such that the majority of dominant circulating clones include isolates from both populations, indicating that global spread of MAB clones is not sequestered to CF contexts. We identify a large clade of M. abscessus harboring the erm(41) T28C mutation, predicted to confer macrolide susceptibility in this otherwise macrolide-resistant species. Identification of multiple evolutionary events within this clade, consistent with regain of wild type, intrinsic macrolide resistance, underscores the critical importance of macrolides in MAB.
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