Evidence map›Paper›PMID 34446581›Full record

ArticleScience (New York, N.Y.)2021

Developmental and evolutionary dynamics of cis-regulatory elements in mouse cerebellar cells.

Ioannis Sarropoulos, Mari Sepp, Robert Frömel, Kevin Leiss, Nils Trost, Evgeny Leushkin, Konstantin Okonechnikov, Piyush Joshi, Peter Giere, Lena M Kutscher and 3 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The molecular evolution of vertebrate organs.Nature ecology & evolution · 2026
    Review
  5. Article
  6. Decoding cnidarian cell type gene regulation.Nature ecology & evolution · 2026
    Article
  7. AAV-PHP.eB Peripheral Delivery and Central Expression in Cre Mice.The Journal of comparative neurology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ioannis Sarropoulos *Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany. h.kaessmann@zmbh.uni-heidelberg.de s.pfister@dkfz.de i.sarropoulos@zmbh.uni-heidelberg.de m.sepp@zmbh.uni-heidelberg.de.ORCID 0000-0002-2242-0562
Mari Sepp *Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany. h.kaessmann@zmbh.uni-heidelberg.de s.pfister@dkfz.de i.sarropoulos@zmbh.uni-heidelberg.de m.sepp@zmbh.uni-heidelberg.de.ORCID 0000-0003-1733-8385
Robert FrömelCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany.ORCID 0000-0002-0438-8677
Kevin LeissCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany.ORCID 0000-0002-5955-6076
Nils TrostCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany.ORCID 0000-0002-5171-018X
Evgeny LeushkinCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany.
Konstantin OkonechnikovHopp Children's Cancer Center (KiTZ) Heidelberg, Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), and German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany.ORCID 0000-0002-3409-2340
Piyush JoshiHopp Children's Cancer Center (KiTZ) Heidelberg, Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), and German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany.ORCID 0000-0002-5631-336X
Peter GiereMuseum für Naturkunde, Leibniz Institute for Evolution and Biodiversity Science, Berlin, Germany.ORCID 0000-0002-5570-0085
Lena M KutscherHopp Children's Cancer Center (KiTZ) Heidelberg, Developmental Origins of Pediatric Cancer Group, German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany.ORCID 0000-0002-1130-4582
Margarida Cardoso-MoreiraCenter for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany.ORCID 0000-0001-6639-3597
Stefan M Pfister *Hopp Children's Cancer Center (KiTZ) Heidelberg, Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), and German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany. h.kaessmann@zmbh.uni-heidelberg.de s.pfister@dkfz.de i.sarropoulos@zmbh.uni-heidelberg.de m.sepp@zmbh.uni-heidelberg.de.ORCID 0000-0002-5447-5322
Henrik Kaessmann *Center for Molecular Biology of Heidelberg University (ZMBH), DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany. h.kaessmann@zmbh.uni-heidelberg.de s.pfister@dkfz.de i.sarropoulos@zmbh.uni-heidelberg.de m.sepp@zmbh.uni-heidelberg.de.ORCID 0000-0001-7563-839X

Funding

European Research Council 615253European Research Council 819894Wellcome Trust FC011171
6 · The paper itself

Abstract

Organ development is orchestrated by cell- and time-specific gene regulatory networks. In this study, we investigated the regulatory basis of mouse cerebellum development from early neurogenesis to adulthood. By acquiring snATAC-seq (single-nucleus assay for transposase accessible chromatin using sequencing) profiles for ~90,000 cells spanning 11 stages, we mapped cerebellar cell types and identified candidate cis

Indexed as

Biological EvolutionRegulatory Elements, TranscriptionalAnimalsCerebellumChromatinDNA, IntergenicFemaleGene Expression Regulation, DevelopmentalGene Regulatory NetworksMaleMiceNeural Stem CellsNeurogenesisNeuronsOpossumsChromatinDNA, Intergenic

Identifiers

PMID34446581
PMCPMC7611596

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.