Evidence map›Paper›PMID 34446572›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Restoring the Molecular Clockwork within the Suprachiasmatic Hypothalamus of an Otherwise Clockless Mouse Enables Circadian Phasing and Stabilization of Sleep-Wake Cycles and Reverses Memory Deficits.

Elizabeth S Maywood, Johanna E Chesham, Raphaelle Winsky-Sommerer, Michael H Hastings

Open access · hybridAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Pharmaceutical biology · 2026
    Review
  2. Article
  3. Review
  4. The sleep-wake history contributes to rhythmic BMAL1 chromatin binding in the cerebral cortex but not in the liver.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. The Mammalian Circadian Time-Keeping System.Journal of Huntington's disease · 2023
    Review
  15. Behavior and physiology in femaleFrontiers in endocrinology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Elizabeth S MaywoodDivision of Neurobiology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom emaywood@mrc-lmb.cam.ac.uk mha@mrc-lmb.cam.ac.uk.ORCID 0000-0002-4557-9955
Johanna E CheshamDivision of Neurobiology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom.ORCID 0000-0002-8981-2667
Raphaelle Winsky-SommererSurrey Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XP, United Kingdom.
Michael H HastingsDivision of Neurobiology, Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom emaywood@mrc-lmb.cam.ac.uk mha@mrc-lmb.cam.ac.uk.ORCID 0000-0001-8576-6651
MRC Laboratory of Molecular Biology · GBUniversity of Surrey · GB

Funding

Medical Research Council MC_U105170643
6 · The paper itself

Abstract

The timing and quality of sleep-wake cycles are regulated by interacting circadian and homeostatic mechanisms. Although the suprachiasmatic nucleus (SCN) is the principal clock, circadian clocks are active across the brain and the respective sleep-regulatory roles of SCN and local clocks are unclear. To determine the specific contribution(s) of the SCN, we used virally mediated genetic complementation, expressing Cryptochrome1 (Cry1) to establish circadian molecular competence in the suprachiasmatic hypothalamus of globally clockless, arrhythmic male

Indexed as

AnimalsCircadian ClocksCircadian RhythmCryptochromesElectroencephalographyElectromyographyMaleMemory DisordersMiceMice, Inbred C57BLMice, KnockoutSleepSuprachiasmatic NucleusWakefulnessCry1 protein, mouseCry2 protein, mouseCryptochromescircadianclockcryptochromehippocampusNREM sleepsleep homeostasis

Identifiers

PMID34446572
PMCPMC8513698
OpenAlexW3194276794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.