ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Differential Effects of Cerebellar Degeneration on Feedforward versus Feedback Control across Speech and Reaching Movements.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Sensorimotor Adaptation of Vocal Pitch Is Impaired in Cerebellar Ataxia.Journal of cognitive neuroscience · 2026Article
- Modeling framework disentangles cerebellar mechanisms in speech feedback control, revealing trade-offs reshaped by degeneration.bioRxiv : the preprint server for biology · 2026Article
- Audiomotor prediction errors drive speech adaptation even in the absence of overt movement.PLoS biology · 2026Article
- Cerebellar contributions to action and cognition: Prediction, timescale, and continuity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Disorders of the Basal Ganglia and Cerebellum: A Comprehensive Review of Speech Sensorimotor Symptoms and Responses to Feedback Perturbations.Neurobiology of language (Cambridge, Mass.) · 2026Review
- The neural underpinnings of cognitive and postural profile of a young adult with congenital cerebellar athrophy: a longitudinal case report.Frontiers in neuroscience · 2026Article
- Formant variability is related to vowel duration across speakers.JASA express letters · 2025Article
- Sensorimotor adaptation of vocal pitch is severely impaired in cerebellar ataxia.bioRxiv : the preprint server for biology · 2025Article
- Feedback and feedforward control are differentially delayed in cerebellar ataxia.bioRxiv : the preprint server for biology · 2025Article
- Divided Attention Has Limited Effects on Speech Sensorimotor Control.Journal of speech, language, and hearing research : JSLHR · 2024Article
- The cerebellum acts as the analog to the medial temporal lobe for sensorimotor memory.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Application of a feedforward control-based intervention for preventing hypothermia in trauma patients in a pre-hospital emergency setting.American journal of translational research · 2024Article
- Do Not Cut Off Your Tail: A Mega-Analysis of Responses to Auditory Perturbation Experiments.Journal of speech, language, and hearing research : JSLHR · 2023Article
- Effects of Gradual and Sudden Introduction of Perturbations on Adaptive Responses to Formant-Shift and Formant-Clamp Perturbations.Journal of speech, language, and hearing research : JSLHR · 2023Article
- Understanding implicit sensorimotor adaptation as a process of proprioceptive re-alignment.eLife · 2022Article
- A single exposure to altered auditory feedback causes observable sensorimotor adaptation in speech.eLife · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Errors that result from a mismatch between predicted movement outcomes and sensory afference are used to correct ongoing movements through feedback control and to adapt feedforward control of future movements. The cerebellum has been identified as a critical part of the neural circuit underlying implicit adaptation across a wide variety of movements (reaching, gait, eye movements, and speech). The contribution of this structure to feedback control is less well understood. Although it has recently been shown in the speech domain that individuals with cerebellar degeneration produce larger online corrections for sensory perturbations than control participants, similar behavior has not been observed in other motor domains. Currently, comparisons across domains are limited by different population samples and potential ceiling effects in existing tasks. To assess the relationship between changes in feedforward and feedback control associated with cerebellar degeneration across motor domains, we evaluated adaptive (feedforward) and compensatory (feedback) responses to sensory perturbations in reaching and speech production in human participants of both sexes with cerebellar degeneration and neurobiologically healthy controls. As expected, the cerebellar group demonstrated impaired adaptation in both reaching and speech. In contrast, the groups did not differ in their compensatory response in either domain. Moreover, compensatory and adaptive responses in the cerebellar group were not correlated within or across motor domains. These results point to a general impairment in feedforward control with spared feedback control in cerebellar degeneration. However, the magnitude of feedforward impairments and potential changes in feedback-based control manifest in a domain-specific manner across individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.