Evidence map›Paper›PMID 34446304›Full record

ReviewOphthalmology2022

Adjustable Sutures in the Treatment of Strabismus: A Report by the American Academy of Ophthalmology.

Gena Heidary, Vinay K Aakalu, Gil Binenbaum, Melinda Y Chang, David G Morrison, Deborah K VanderVeen, Scott R Lambert, Rupal H Trivedi, Jennifer A Galvin, Stacy L Pineles

Open access · greenAbstract readReview
In one paragraph

Review in Ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Strabismus Surgery in Orthophoric Patients with Abduction Limitation.Clinical ophthalmology (Auckland, N.Z.) · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Gena HeidaryDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Vinay K AakaluIllinois Eye and Ear Infirmary, University of Illinois College of Medicine at Chicago, Chicago, Illinois.
Gil BinenbaumDepartment of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Melinda Y ChangChildren's Hospital of Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California.
David G MorrisonVanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee.
Deborah K VanderVeenDepartment of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
Scott R LambertDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, California.
Rupal H TrivediStorm Eye Institute, Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina.
Jennifer A GalvinEye Physicians and Surgeons PC, Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, Connecticut.
Stacy L PinelesJules Stein Eye Institute, Los Angeles, California.
Boston Children's Hospital · USChildren's Hospital of Philadelphia · USHarvard University · USMedical University of South Carolina · USStanford University · USUniversity of Illinois Chicago · USUniversity of Southern California · USVanderbilt University Medical Center · US

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
NEI NIH HHS P30 EY026877
6 · The paper itself

Abstract

purposeTo review the scientific literature that evaluates the effectiveness of adjustable sutures in the management of strabismus for adult and pediatric patients.

methodsLiterature searches were performed in the PubMed database through April 2021 with no date limitations and were restricted to publications in English. The searches identified 551 relevant citations, of which 55 were reviewed in full text. Of these, 17 articles met the inclusion criteria and were assigned a level of evidence rating by the panel methodologist. The search included all randomized controlled studies regardless of study size and cohort studies of 100 or more patients comparing the adjustable versus nonadjustable suture technique, with a focus on motor alignment outcomes or reoperation rates.

resultsThe literature search yielded no level I studies. Of the 17 articles that met the inclusion criteria, 11 were rated level II and 6 were rated level III. Among the 12 studies that focused on motor alignment outcomes, 4 small randomized clinical trials (RCTs) did not find a statistically significant difference between groups, although they were powered to detect only very large differences. Seven of 8 nonrandomized studies found a statistically significant difference in motor alignment success in favor of the adjustable suture technique, both overall and in certain subgroups of patients. Successful motor alignment was seen in both exotropia (in 3 studies that were not limited to children) and esotropia (in 1 study of adults and 2 of children). The majority of included studies that reported on reoperation rates found the rates to be lower in patients who underwent strabismus surgery with adjustable sutures, but this finding was not uniformly demonstrated.

conclusionsAlthough there are no level I studies evaluating the effectiveness of adjustable sutures for strabismus surgery, the majority of nonrandomized studies that met the inclusion criteria for this assessment reported an advantage of the adjustable suture technique over the nonadjustable technique with respect to motor alignment outcomes. This finding was not uniformly demonstrated among all studies reviewed and warrants further investigation in the development and analysis of adjustable suture techniques.

Indexed as

Suture TechniquesAcademies and InstitutesAdultChildHumansOculomotor MusclesOphthalmologic Surgical ProceduresOphthalmologyStrabismusSuturesTechnology Assessment, BiomedicalUnited StatesVision, Binocularadjustable suturesamblyopiadiplopiaesotropiaexotropiaextraocular muscle surgeryGraveshyperthyroidismhypertropiaoculomotor musclessquintstrabismusthyroid myopathy

Identifiers

PMID34446304
PMCPMC10187043
OpenAlexW3194456209

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.